A study involving more than 8,000 participants has shown that people with a family history of diabetes see their risk of prediabetes increase by 26%. The research is published in Diabetologia, the journal of the European Association for the Study of Diabetes, and is by Dr Andreas Fritsche and colleagues from the German Center for Diabetes Research.
Prediabetes is a condition most often described as the 'state between normal blood sugar control and full diabetes', and indeed prediabetes progresses to full blown diabetes in up to 20% of individuals affected per year.
Prediabetes can take two forms: impaired fasting glycaemia (IFG), whereby levels of glucose in the fast state are higher than normal but not high enough to be classed as diabetes; and also impaired glucose tolerance (IGT), where blood sugar levels are abnormal due to increased insulin resistance. While it is known that a family history of type 2 diabetes increases the risk of full blown diabetes, research has not yet explored whether such a family history increases the risk of prediabetes in either form.
In this study Fritsche and colleagues analysed 8,106 non-diabetic individuals of European origin collected from the study centres of the German Center for Diabetes Research.* Of these, 5,482 had normal glucose tolerance, and 2,624 had IFG and/or IGT n=2,624. They analysed whether having at least one first degree relative with diabetes is associated with prediabetes.
A family history of diabetes was found to increase the crude, unadjusted risk for prediabetes (IFG and/or IGT) by 40%. This increased risk fell to 26% when the analysis took account of age, sex, and BMI of participants.
When different types of prediabetes were considered, family history increased the risk of isolated IFG by 37%, of isolated IGT by 25%, and the two combined by 64%. However overall, when adjusted for BMI, the association between family history and prediabetes was seen only in non-obese individuals (BMI<30 kg/m2). The authors say: "Our data suggest that a family history of diabetes is associated with prediabetes in non-obese rather than in obese individuals. This might indicate the effect of family history on prediabetes becomes readily measurable only when not overshadowed by strong risk factors such as obesity."
They conclude: "We found that family history is an important risk factor for prediabetes, especially for combined IGT and IFG. Its relevance seems to be more evident in the non-obese."
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A study involving more than 8,000 participants has shown that people with a family history of diabetes see their risk of prediabetes increase by 26%. The research is published in Diabetologia, the journal of the European Association for the Study of Diabetes, and is by Dr Andreas Fritsche and colleagues from the German Center for Diabetes Research.
Prediabetes is a condition most often described as the 'state between normal blood sugar control and full diabetes', and indeed prediabetes progresses to full blown diabetes in up to 20% of individuals affected per year.
Prediabetes can take two forms: impaired fasting glycaemia (IFG), whereby levels of glucose in the fast state are higher than normal but not high enough to be classed as diabetes; and also impaired glucose tolerance (IGT), where blood sugar levels are abnormal due to increased insulin resistance. While it is known that a family history of type 2 diabetes increases the risk of full blown diabetes, research has not yet explored whether such a family history increases the risk of prediabetes in either form.
In this study Fritsche and colleagues analysed 8,106 non-diabetic individuals of European origin collected from the study centres of the German Center for Diabetes Research.* Of these, 5,482 had normal glucose tolerance, and 2,624 had IFG and/or IGT n=2,624. They analysed whether having at least one first degree relative with diabetes is associated with prediabetes.
A family history of diabetes was found to increase the crude, unadjusted risk for prediabetes (IFG and/or IGT) by 40%. This increased risk fell to 26% when the analysis took account of age, sex, and BMI of participants.
When different types of prediabetes were considered, family history increased the risk of isolated IFG by 37%, of isolated IGT by 25%, and the two combined by 64%. However overall, when adjusted for BMI, the association between family history and prediabetes was seen only in non-obese individuals (BMI<30 kg/m2). The authors say: "Our data suggest that a family history of diabetes is associated with prediabetes in non-obese rather than in obese individuals. This might indicate the effect of family history on prediabetes becomes readily measurable only when not overshadowed by strong risk factors such as obesity."
They conclude: "We found that family history is an important risk factor for prediabetes, especially for combined IGT and IFG. Its relevance seems to be more evident in the non-obese."
Explore further: Millions on verge of diabetes don't know it, CDC reports
Medical Xpress on facebook
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Millions on verge of diabetes don't know it, CDC reports
Mar 21, 2013
(HealthDay)—Only 11 percent of the estimated 79 million Americans who are at risk for diabetes know they are at risk, federal health officials reported Thursday.
Two distinct high-risk diabetes populations ID'd in children
Dec 19, 2012
(HealthDay)—Children with high-risk A1C (hrA1C) and impaired fasting glucose (IFG) define different populations, with differentially increased risk markers, according to research published online Nov. 27 ...
Treatment of sleep apnea improves glucose levels in prediabetes
May 20, 2013
Optimal treatment of sleep apnea in patients with prediabetes improves blood sugar (glucose) levels and thus can reduce cardiometabolic risk, according to a study to be presented at the ATS 2013 International Conference in ...
New NIH fact sheet explains test for diabetes, prediabetes
Jan 27, 2012
A new fact sheet from the National Institutes of Health explains the A1C test, a widely used and important test to diagnose type 2 diabetes and prediabetes, and to monitor blood glucose levels of people with type 1 and type ...
Genetic risk score linked to increased risk of diabetes
Jul 30, 2013
(HealthDay)—A genetic risk score based on 46 gene variants linked to type 2 diabetes is associated with increases in the risk of type 2 diabetes and declines in glucose control and beta-cell function, according ...
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Ultrawide field retinal imaging improves telehealth evaluation
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Metformin usually adequate for control of gestational diabetes
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