(Medical Xpress)—Researchers at the University of Adelaide have discovered that the way the gut "tastes" sweet food may be defective in sufferers of type 2 diabetes, leading to problems with glucose uptake.
This is the first time that abnormal control of so-called "sweet taste receptors" in the human intestine has been described by researchers. The work could have implications for a range of health and nutrition problems experienced by diabetes patients.
Dr Richard Young, Senior Postdoctoral Researcher in the University of Adelaide's Nerve-Gut Research Laboratory, says taste buds aren't the only way the body detects sweetness.
"When we talk about 'sweet taste', most people think of tasting sweet food on our tongue, but scientists have discovered that sweet taste receptors are present in a number of sites in the human body. We're now just beginning to understand the importance of the sweet taste receptors in the human intestine and what this means for sufferers of type 2 diabetes," Dr Young says.
In his study, Dr Young compared healthy adults with type 2 diabetic adults. He found that the control of sweet taste receptors in the intestine of the healthy adults enabled their bodies to effectively regulate glucose intake 30 minutes after exposure to glucose. However, abnormalities in the diabetic adults resulted in more rapid glucose uptake.
"When sweet taste receptors in the intestine detect glucose, they trigger a response that may regulate the way glucose is absorbed by the intestine. Our studies show that in diabetes patients, the glucose is absorbed more rapidly and in greater quantities than in healthy adults," Dr Young says.
"This shows that diabetes is not just a disorder of the pancreas and of insulin - the gut plays a bigger role than researchers have previously considered. This is because the body's own management of glucose uptake may rely on the actions of sweet taste receptors, and these appear to be abnormally controlled in people with type 2 diabetes."
Dr Young says more research is needed to better understand these mechanisms in the gut.
"So far, we've seen what happens in people 30 minutes after glucose is delivered to the intestine, but we also need to study what happens over the entire period of digestion. There are also questions about whether or not the body responds differently to artificial sweeteners compared with natural glucose," he says.
"By gaining a better understanding of how these mechanisms in the gut work, we hope that eventually this will assist to better manage or treat diabetes in the future."
This study has been funded by the National Health and Medical Research Council (NHMRC) and Diabetes Australia. The results have been published online ahead of print in the international journal Diabetes.
Explore further: Artificial sweeteners may do more than sweeten
More information: diabetes.diabetesjournals.org/content/early/2013/06/03/db13-0581.abstract
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(Medical Xpress)—Researchers at the University of Adelaide have discovered that the way the gut "tastes" sweet food may be defective in sufferers of type 2 diabetes, leading to problems with glucose uptake.
This is the first time that abnormal control of so-called "sweet taste receptors" in the human intestine has been described by researchers. The work could have implications for a range of health and nutrition problems experienced by diabetes patients.
Dr Richard Young, Senior Postdoctoral Researcher in the University of Adelaide's Nerve-Gut Research Laboratory, says taste buds aren't the only way the body detects sweetness.
"When we talk about 'sweet taste', most people think of tasting sweet food on our tongue, but scientists have discovered that sweet taste receptors are present in a number of sites in the human body. We're now just beginning to understand the importance of the sweet taste receptors in the human intestine and what this means for sufferers of type 2 diabetes," Dr Young says.
In his study, Dr Young compared healthy adults with type 2 diabetic adults. He found that the control of sweet taste receptors in the intestine of the healthy adults enabled their bodies to effectively regulate glucose intake 30 minutes after exposure to glucose. However, abnormalities in the diabetic adults resulted in more rapid glucose uptake.
"When sweet taste receptors in the intestine detect glucose, they trigger a response that may regulate the way glucose is absorbed by the intestine. Our studies show that in diabetes patients, the glucose is absorbed more rapidly and in greater quantities than in healthy adults," Dr Young says.
"This shows that diabetes is not just a disorder of the pancreas and of insulin - the gut plays a bigger role than researchers have previously considered. This is because the body's own management of glucose uptake may rely on the actions of sweet taste receptors, and these appear to be abnormally controlled in people with type 2 diabetes."
Dr Young says more research is needed to better understand these mechanisms in the gut.
"So far, we've seen what happens in people 30 minutes after glucose is delivered to the intestine, but we also need to study what happens over the entire period of digestion. There are also questions about whether or not the body responds differently to artificial sweeteners compared with natural glucose," he says.
"By gaining a better understanding of how these mechanisms in the gut work, we hope that eventually this will assist to better manage or treat diabetes in the future."
This study has been funded by the National Health and Medical Research Council (NHMRC) and Diabetes Australia. The results have been published online ahead of print in the international journal Diabetes.
Explore further: Artificial sweeteners may do more than sweeten
More information: diabetes.diabetesjournals.org/content/early/2013/06/03/db13-0581.abstract
Medical Xpress on facebook
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Your gut has taste receptors
Aug 20, 2007
Researchers in the Department of Neuroscience at Mount Sinai School of Medicine have identified taste receptors in the human intestines. The taste receptor T1R3 and the taste G protein gustducin are critical to sweet taste ...
Artificial sweeteners may do more than sweeten
May 29, 2013
Researchers at Washington University School of Medicine in St. Louis have found that a popular artificial sweetener can modify how the body handles sugar.
Tasting fructose with the pancreas
Feb 06, 2012
Taste receptors on the tongue help us distinguish between safe food and food that's spoiled or toxic. But taste receptors are now being found in other organs, too. In a study published online the week of February ...
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Dec 21, 2012
Despite more than 25 years of research on antiobesity drugs, few medications have shown long-term success. Now researchers reporting online on December 21 in the Cell Press journal Trends in Endocrinology & Metabolism say th ...
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Family history of diabetes increases the risk of prediabetes by 26 percent, with effect most evident in non-obese
Aug 21, 2013
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