Doctoral research student Shuang Zhou, and Erxi Wu, assistant professor of pharmaceutical sciences, have co-written a paper, "1, 25(OH)2D3 Inhibits Hepatocellular Carcinoma Development Through Reducing Secretion of Inflammatory Cytokines from Immunocytes" which was published in Current Medicinal Chemistry.
Low vitamin D levels in blood are associated with various types of diseases such as osteomalacia and cancer. According to the authors, epidemiological and clinical studies have indicated that low vitamin D activity is not only associated with an increased cancer risk and a more aggressive tumor growth, but also connected with an aggravated liver damage caused by chronic inflammation. Meanwhile, increasing evidence has demonstrated 1,25-(OH)2D3, the most biologically active metabolite of vitamin D, can inhibit inflammatory response in some chronic inflammatory associated cancer. However, the interaction between 1,25-(OH)2D3 and inflammation during hepatocellular carcinoma initiation and progression is not yet clear.
Researchers led by Wu and Qingyong Ma at Xi'an Jiaotong University, China, report an anti-tumorigenesis effect of 1,25-(OH)2D3 via decreasing secretion of inflammatory cytokines in hepatocellular carcinoma.
Wu said, "The effects of vitamin D supplementation on health are uncertain previously, now more and more data show that vitamin D plays very important roles in human health, especially for people living in areas with low sunshine, such as North Dakota. In fact, the toxicity for excess of vitamin D is rare."
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Doctoral research student Shuang Zhou, and Erxi Wu, assistant professor of pharmaceutical sciences, have co-written a paper, "1, 25(OH)2D3 Inhibits Hepatocellular Carcinoma Development Through Reducing Secretion of Inflammatory Cytokines from Immunocytes" which was published in Current Medicinal Chemistry.
Low vitamin D levels in blood are associated with various types of diseases such as osteomalacia and cancer. According to the authors, epidemiological and clinical studies have indicated that low vitamin D activity is not only associated with an increased cancer risk and a more aggressive tumor growth, but also connected with an aggravated liver damage caused by chronic inflammation. Meanwhile, increasing evidence has demonstrated 1,25-(OH)2D3, the most biologically active metabolite of vitamin D, can inhibit inflammatory response in some chronic inflammatory associated cancer. However, the interaction between 1,25-(OH)2D3 and inflammation during hepatocellular carcinoma initiation and progression is not yet clear.
Researchers led by Wu and Qingyong Ma at Xi'an Jiaotong University, China, report an anti-tumorigenesis effect of 1,25-(OH)2D3 via decreasing secretion of inflammatory cytokines in hepatocellular carcinoma.
Wu said, "The effects of vitamin D supplementation on health are uncertain previously, now more and more data show that vitamin D plays very important roles in human health, especially for people living in areas with low sunshine, such as North Dakota. In fact, the toxicity for excess of vitamin D is rare."
Explore further: Who benefits from vitamin D?
Medical Xpress on facebook
Related Stories
Who benefits from vitamin D?
Aug 13, 2013
Studying the expression of genes that are dependent on vitamin D makes it possible to identify individuals who will benefit from vitamin D supplementation, shows a University of Eastern Finland study published recently in ...
Researchers link stress and pancreatic cancer in new paper
Feb 15, 2013
Pancreatic cancer is a deadly disease with increased incidences in the recent years. According to NDSU researchers, epidemiological data show chronic stress in a negative social and psychological state such as depression ...
Researchers discover how vitamin D inhibits inflammation
Feb 23, 2012
Researchers at National Jewish Health have discovered specific molecular and signaling events by which vitamin D inhibits inflammation. In their experiments, they showed that low levels of Vitamin D, comparable to levels ...
More than one-third of populations worldwide may have low levels of vitamin D, study shows
Sep 04, 2013
A new systematic review published in the British Journal of Nutrition, is one of the first to focus on patterns of vitamin D status worldwide and in key population subgroups, using continuous values for 25(OH)D to improv ...
Study reveals potential immune benefits of vitamin D supplements in healthy individuals
Mar 20, 2013
Research from Boston University School of Medicine (BUSM) shows that improving vitamin D status by increasing its level in the blood could have a number of non-skeletal health benefits. The study, published online in PLOS ON ...
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38 minutes ago
(Medical Xpress)—Determining whether a patient's lung cancer has spread to nearby lymph nodes is critical for identifying the most effective therapy, but it usually requires surgery. A new study suggests, however, that ...
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2 hours ago
(HealthDay)—The U.S. Preventive Services Task Force (USPSTF) recommends that women at increased risk of breast cancer be prescribed tamoxifen or raloxifene for risk reduction, according to a final Recommendation ...
Marriage associated with better cancer outcomes, study finds
15 hours ago
People who are married when diagnosed with cancer live longer than those who are not, report researchers at Dana-Farber Cancer Institute and Brigham and Women's Hospital. Married patients also tended to have cancers diagnosed ...
Researchers erase human brain tumor cells in mice
18 hours ago
Working with mice, Johns Hopkins researchers have discovered that weeks of treatment with a repurposed FDA-approved drug halted the growth of—and ultimately left no detectable trace of—brain tumor cells taken from adult ...
Long-term hormonal therapy in intermediate-risk PCa patients does not improve overall survival
20 hours ago
A secondary analysis of the historic RTOG 9202 prostate cancer trial examined results of men with intermediate-risk prostate cancer who had received long-term hormonal therapy after radiation therapy, and concluded that there ...
Fewer weeks of hormone therapy before radiation reduces side effects in intermediate risk PCa
21 hours ago
A shorter course of androgen suppression therapy prior to radiation therapy, when compared to a longer course of androgen suppression therapy, yields favorable outcomes and fewer adverse effects for intermediate-risk prostate ...
User comments
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