Prenatal exposure to antiepileptic medications was associated with an increased risk of impaired fine motor skills (small muscle movements) in children at age 6 months, but breastfeeding by women taking the medications was not associated with any harmful effects on child development at ages 6 to 36 months, according to a report published by JAMA Neurology.
Few studies have examined development during the first months of life of children of mothers with epilepsy, according to background in the study by Gyri Veiby, M.D., of the University of Bergen, Norway, and colleagues.
Researchers used data from the Norwegian Mother and Child Cohort Study from 1999 to 2009, in which mothers reported children's motor and social skills, language and behavior at 6, 18 and 36 months of age. Women also provided information on breastfeeding during the first year.
Exposure to antiepileptic drugs during pregnancy was reported in 223 children, mostly to a single drug (n=182).
At age 6 months, a higher proportion of infants whose mothers took antiepileptic drugs had impaired fine motor skills compared to the reference group (11.5 percent vs. 4.8 percent). The use of multiple antiepileptic medications was associated with impaired fine motor and social skills, according to the study results.
Breastfeeding by mothers using antiepileptic drugs was not associated with adverse development at ages 6 to 36 months in nursing children, according to the study.
"Women with epilepsy should be encouraged to breastfeed their children irrespective of antiepileptic medication use," the study concludes.
In an editorial, Paul C. Van Ness, M.D., of the University of Texas Southwestern Medical Center, Dallas, writes: "Pregnant women with epilepsy often ask whether they will be able to breastfeed. Many have been given conflicting advice when there were scant data to answer the question."
"This study adds additional evidence that long-term breastfeeding is safe and perhaps even beneficial to infants of mothers taking AEDs [antiepileptic drugs]," Van Ness continues.
"This should be an important area of discussion with any woman of childbearing potential well in advance of pregnancy using the best available information. Thus, a woman should take folic acid supplements, received AED monotherapy whenever possible, and take the lowest effective dose of medication," the editorial concludes.
Explore further: Antiepileptic drug use while pregnant impacts early child development
More information: JAMA Neurol. Published online September 23, 2013. DOI: 10.1001/jamaneurol.2013.4290
JAMA Neurol. Published online September 23, 2013. DOI: 10.1001/jamaneurol.2013.4348
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Prenatal exposure to antiepileptic medications was associated with an increased risk of impaired fine motor skills (small muscle movements) in children at age 6 months, but breastfeeding by women taking the medications was not associated with any harmful effects on child development at ages 6 to 36 months, according to a report published by JAMA Neurology.
Few studies have examined development during the first months of life of children of mothers with epilepsy, according to background in the study by Gyri Veiby, M.D., of the University of Bergen, Norway, and colleagues.
Researchers used data from the Norwegian Mother and Child Cohort Study from 1999 to 2009, in which mothers reported children's motor and social skills, language and behavior at 6, 18 and 36 months of age. Women also provided information on breastfeeding during the first year.
Exposure to antiepileptic drugs during pregnancy was reported in 223 children, mostly to a single drug (n=182).
At age 6 months, a higher proportion of infants whose mothers took antiepileptic drugs had impaired fine motor skills compared to the reference group (11.5 percent vs. 4.8 percent). The use of multiple antiepileptic medications was associated with impaired fine motor and social skills, according to the study results.
Breastfeeding by mothers using antiepileptic drugs was not associated with adverse development at ages 6 to 36 months in nursing children, according to the study.
"Women with epilepsy should be encouraged to breastfeed their children irrespective of antiepileptic medication use," the study concludes.
In an editorial, Paul C. Van Ness, M.D., of the University of Texas Southwestern Medical Center, Dallas, writes: "Pregnant women with epilepsy often ask whether they will be able to breastfeed. Many have been given conflicting advice when there were scant data to answer the question."
"This study adds additional evidence that long-term breastfeeding is safe and perhaps even beneficial to infants of mothers taking AEDs [antiepileptic drugs]," Van Ness continues.
"This should be an important area of discussion with any woman of childbearing potential well in advance of pregnancy using the best available information. Thus, a woman should take folic acid supplements, received AED monotherapy whenever possible, and take the lowest effective dose of medication," the editorial concludes.
Explore further: Antiepileptic drug use while pregnant impacts early child development
More information: JAMA Neurol. Published online September 23, 2013. DOI: 10.1001/jamaneurol.2013.4290
JAMA Neurol. Published online September 23, 2013. DOI: 10.1001/jamaneurol.2013.4348
Medical Xpress on facebook
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Antiepileptic drug use while pregnant impacts early child development
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Children whose mothers took antiepileptic drugs (AEDs) while pregnant are at increased risk of early development issues, according to a new study published in Epilepsia, a journal published by Wiley on behalf of the Intern ...
Study reveals long-term effects on child IQ of epilepsy drug valproate during pregnancy
Jan 22, 2013
Research published today in the Lancet Neurology shows that taking the antiepileptic drug valproate during pregnancy affects the IQ of children up to the age of six.
Fetal exposure to antiepileptic drug valproate impairs cognitive development
Mar 20, 2013
(Medical Xpress)—The effects of antiepileptic drugs during pregnancy have long been a concern of clinicians and women of childbearing age whose seizures can only be controlled by medications. In 1999, a ...
Exposure to antiepileptic drug in womb linked to autism risk
Jan 30, 2013
Children whose mothers take the antiepileptic drug sodium valproate while pregnant are at significantly increased risk of autism and other neurodevelopmental disorders, suggests a small study published online in the Journal of ...
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(HealthDay)—Pregnant women who struggle with migraine headaches should never use medicines containing the ingredient valproate because they can lower the IQ scores of their children, the U.S. Food and Drug ...
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© Medical Xpress 2011-2013, Phys.org network
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