First-degree, second-degree, and third-degree relatives of patients diagnosed with papillary thyroid cancer are at significantly increased risk of developing the disease, according to research published online Oct. 3 in JAMA Otolaryngology-Head & Neck Surgery.
(HealthDay)—First-degree, second-degree, and third-degree relatives of patients diagnosed with papillary thyroid cancer (PTC) are at significantly increased risk of developing the disease, according to research published online Oct. 3 in JAMA Otolaryngology-Head & Neck Surgery.
Gretchen M. Oakley, M.D., of the University of Utah in Salt Lake City, and colleagues retrospectively reviewed data for 1966 to 2011 from the Utah Population Database to assess the familial risk of PTC.
The researchers found that, compared with controls, relatives of PTC probands were at significantly increased risk of being diagnosed with the cancer, including first-degree relatives (5.4-fold), second-degree relatives (2.2-fold), and third-degree relatives (1.8-fold). Siblings of patients with PTC were at the highest risk of developing the cancer (odds ratio, 6.8), while spouses of probands were not at significantly increased risk.
"Translational studies are needed to better define the genetic predisposition to familial papillary thyroid cancer and for the development and implementation of optimal screening approaches," the authors write.
Explore further: Forensic familial search methods carry risk of certain false matches
More information: Abstract
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First-degree, second-degree, and third-degree relatives of patients diagnosed with papillary thyroid cancer are at significantly increased risk of developing the disease, according to research published online Oct. 3 in JAMA Otolaryngology-Head & Neck Surgery.
(HealthDay)—First-degree, second-degree, and third-degree relatives of patients diagnosed with papillary thyroid cancer (PTC) are at significantly increased risk of developing the disease, according to research published online Oct. 3 in JAMA Otolaryngology-Head & Neck Surgery.
Gretchen M. Oakley, M.D., of the University of Utah in Salt Lake City, and colleagues retrospectively reviewed data for 1966 to 2011 from the Utah Population Database to assess the familial risk of PTC.
The researchers found that, compared with controls, relatives of PTC probands were at significantly increased risk of being diagnosed with the cancer, including first-degree relatives (5.4-fold), second-degree relatives (2.2-fold), and third-degree relatives (1.8-fold). Siblings of patients with PTC were at the highest risk of developing the cancer (odds ratio, 6.8), while spouses of probands were not at significantly increased risk.
"Translational studies are needed to better define the genetic predisposition to familial papillary thyroid cancer and for the development and implementation of optimal screening approaches," the authors write.
Explore further: Forensic familial search methods carry risk of certain false matches
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2013 HealthDay. All rights reserved.
Medical Xpress on facebook
Related Stories
Forensic familial search methods carry risk of certain false matches
Aug 14, 2013
Forensic DNA-based familial search methods may mistakenly identify individuals in a database as siblings or parents of an unknown perpetrator, when in fact they are distant relatives, according to research published August ...
Association between genetic mutation and risk of death for patients with thyroid cancer
Apr 09, 2013
Presence of the genetic mutation BRAF V600E was significantly associated with increased cancer-related death among patients with papillary thyroid cancer (PTC); however, because overall mortality in PTC is low and the association ...
Patient decision aid beneficial in papillary thyroid cancer
Jul 06, 2012
(HealthDay) -- Patients with early-stage papillary thyroid cancer (PTC) may benefit from the use of a patient-directed computerized decision aid (DA) to provide medical knowledge and resolve decisional conflicts ...
Study suggests obese patients have more advanced, aggressive papillary thyroid cancer
May 21, 2012
A review of medical records of patients treated at an academic tertiary care center suggests that obese patients present to their physicians with more advanced stage and more aggressive forms of papillary thyroid cancer (PTC), ...
Large study reveals increased cancer risks associated with family history of the disease
Jul 24, 2013
A family history of cancer increases the risk of other members of the family developing not only the same cancer (known as a concordant cancer) but also a different (discordant) cancer, according to a large study of 23,000 ...
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28 minutes ago
Got heartburn? More than 60 million adults in the U.S. have acid reflux, or heartburn, and approximately 10 percent are at risk for developing esophageal cancer, due in part to complications from Barrett's esophagus. But ...
Battling defiant leukemia cells
3 hours ago
Two gene alterations pair up to promote the growth of leukemia cells and their escape from anti-cancer drugs, according to a study in The Journal of Experimental Medicine.
Examination of less-invasive surgical procedure to detect cancer in lymph nodes near breast
3 hours ago
Judy C. Boughey, M.D., Kelly K. Hunt, M.D., and colleagues for the Alliance for Clinical Trials in Oncology conducted a study to determine the false-negative rate of sentinel lymph node surgery in patients with node-positive ...
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