©2013, Mary Ann Liebert, Inc., publishers
Cancer immunotherapy can successfully use the body's own immune system to kill tumor cells. But some current approaches to stimulate an antitumor immune response are short-lived, with limited clinical effectiveness. A new gene transfer strategy that introduces modified, immune-stimulating human stem cells is both feasible and effective for achieving persistent immunotherapy to treat leukemias and lymophomas, according to a study published in Human Gene Therapy.
Satiro Nakamura De Oliveira and coauthors from the David Geffen School of Medicine, University of California, Los Angeles and University of Texas MD Anderson Cancer Center, Houston, describe the gene transfer method they developed to deliver chimeric antigen receptors, or CARS, that direct the immune system to target tumor cells derived from B-lymphocytes.
In the article "Modification of Hematopoietic Stem/Progenitor Cells with CD19-specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy" the authors show that by packaging the CARS in human hematopoietic stem cells, the immunotherapeutic receptors will be produced in the bloodstream for a long period of time. This persistent expression should improve their effectiveness in the treatment of blood cancers such as leukemia and lymphoma.
"This study represents an interesting new direction for an approach that has generated substantial interest," says Dr. Wilson, Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.
Explore further: Some immune cells appear to aid cancer cell growth, study finds
More information: The article is available on the Human Gene Therapy website.
Medical Xpress on facebook
Related Stories
Some immune cells appear to aid cancer cell growth, study finds
Sep 05, 2013
The immune system is normally known for protecting the body from illness. But a subset of immune cells appear to be doing more harm than good.
New anti-tumor cell therapy strategies are more effective
Oct 25, 2012
Targeted T-cells can seek out and destroy tumor cells that carry specific antigen markers. Two novel anti-tumor therapies that take advantage of this T-cell response are described in articles published in Human Gene Therapy, a peer ...
Stem cells, potential source of cancer-fighting T cells
Sep 20, 2011
Adult stem cells from mice converted to antigen-specific T cells -- the immune cells that fight cancer tumor cells -- show promise in cancer immunotherapy and may lead to a simpler, more efficient way to use the body's immune ...
Adoptive cell transfer: New technique could make cell-based immune therapies for cancer safer, more effective
Dec 16, 2012
A team led by Michel Sadelain, MD, PhD, Director of the Center for Cell Engineering at Memorial Sloan-Kettering Cancer Center, has shown for the first time the effectiveness of a new technique that could allow the development ...
Scientists identify targets for melanoma immunotherapy
Sep 10, 2013
Using a highly sensitive technology called NanoString, researchers have identified seven targets that could potentially be used to develop new immunotherapies for patients with metastatic melanoma, according to a study published ...
Recommended for you
Smartphone app brings genetic analysis to the palm of your hand
22 hours ago
Until now, understanding and using genetic information has depended on the scientists and doctors who do the testing. No longer.
Two genes linked to increased risk for eating disorders
23 hours ago
Eating disorders like anorexia nervosa and bulimia often run in families, but identifying specific genes that increase a person's risk for these complex disorders has proved difficult.
Gene variant linked to prognosis in inflammatory diseases
Oct 08, 2013
(Medical Xpress)—Researchers have identified a gene that is linked to long term disease outcome in Crohn's disease, a common inflammatory bowel disorder, and rheumatoid arthritis. The findings reveal targets ...
Unexpected genomic change through 400 years of French-Canadian history
Oct 08, 2013
Researchers at the Sainte-Justine University Hospital Center and University of Montreal have discovered that the genomic signature inherited by today's 6 million French Canadians from the first 8,500 French settlers who colonized ...
Ethical issues as scientists peek into baby genes
Oct 07, 2013
Little Amelia Sloan is a pioneer: Shortly after her birth, scientists took drops of the healthy baby's blood to map her genetic code.
Researchers find six new Sjogren's syndrome genes
Oct 06, 2013
With the completion of the first genome-wide association study for Sjögren's syndrome, an international coalition of researchers led by scientists at the Oklahoma Medical Research Foundation has identified six new disease-related ...
User comments
© Medical Xpress 2011-2013, Phys.org network
©2013, Mary Ann Liebert, Inc., publishers
Cancer immunotherapy can successfully use the body's own immune system to kill tumor cells. But some current approaches to stimulate an antitumor immune response are short-lived, with limited clinical effectiveness. A new gene transfer strategy that introduces modified, immune-stimulating human stem cells is both feasible and effective for achieving persistent immunotherapy to treat leukemias and lymophomas, according to a study published in Human Gene Therapy.
Satiro Nakamura De Oliveira and coauthors from the David Geffen School of Medicine, University of California, Los Angeles and University of Texas MD Anderson Cancer Center, Houston, describe the gene transfer method they developed to deliver chimeric antigen receptors, or CARS, that direct the immune system to target tumor cells derived from B-lymphocytes.
In the article "Modification of Hematopoietic Stem/Progenitor Cells with CD19-specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy" the authors show that by packaging the CARS in human hematopoietic stem cells, the immunotherapeutic receptors will be produced in the bloodstream for a long period of time. This persistent expression should improve their effectiveness in the treatment of blood cancers such as leukemia and lymphoma.
"This study represents an interesting new direction for an approach that has generated substantial interest," says Dr. Wilson, Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.
Explore further: Some immune cells appear to aid cancer cell growth, study finds
More information: The article is available on the Human Gene Therapy website.
Medical Xpress on facebook
Related Stories
Some immune cells appear to aid cancer cell growth, study finds
Sep 05, 2013
The immune system is normally known for protecting the body from illness. But a subset of immune cells appear to be doing more harm than good.
New anti-tumor cell therapy strategies are more effective
Oct 25, 2012
Targeted T-cells can seek out and destroy tumor cells that carry specific antigen markers. Two novel anti-tumor therapies that take advantage of this T-cell response are described in articles published in Human Gene Therapy, a peer ...
Stem cells, potential source of cancer-fighting T cells
Sep 20, 2011
Adult stem cells from mice converted to antigen-specific T cells -- the immune cells that fight cancer tumor cells -- show promise in cancer immunotherapy and may lead to a simpler, more efficient way to use the body's immune ...
Adoptive cell transfer: New technique could make cell-based immune therapies for cancer safer, more effective
Dec 16, 2012
A team led by Michel Sadelain, MD, PhD, Director of the Center for Cell Engineering at Memorial Sloan-Kettering Cancer Center, has shown for the first time the effectiveness of a new technique that could allow the development ...
Scientists identify targets for melanoma immunotherapy
Sep 10, 2013
Using a highly sensitive technology called NanoString, researchers have identified seven targets that could potentially be used to develop new immunotherapies for patients with metastatic melanoma, according to a study published ...
Recommended for you
Smartphone app brings genetic analysis to the palm of your hand
22 hours ago
Until now, understanding and using genetic information has depended on the scientists and doctors who do the testing. No longer.
Two genes linked to increased risk for eating disorders
23 hours ago
Eating disorders like anorexia nervosa and bulimia often run in families, but identifying specific genes that increase a person's risk for these complex disorders has proved difficult.
Gene variant linked to prognosis in inflammatory diseases
Oct 08, 2013
(Medical Xpress)—Researchers have identified a gene that is linked to long term disease outcome in Crohn's disease, a common inflammatory bowel disorder, and rheumatoid arthritis. The findings reveal targets ...
Unexpected genomic change through 400 years of French-Canadian history
Oct 08, 2013
Researchers at the Sainte-Justine University Hospital Center and University of Montreal have discovered that the genomic signature inherited by today's 6 million French Canadians from the first 8,500 French settlers who colonized ...
Ethical issues as scientists peek into baby genes
Oct 07, 2013
Little Amelia Sloan is a pioneer: Shortly after her birth, scientists took drops of the healthy baby's blood to map her genetic code.
Researchers find six new Sjogren's syndrome genes
Oct 06, 2013
With the completion of the first genome-wide association study for Sjögren's syndrome, an international coalition of researchers led by scientists at the Oklahoma Medical Research Foundation has identified six new disease-related ...
User comments
© Medical Xpress 2011-2013, Phys.org network
0 comments:
Post a Comment