An international research team led by medical scientists at the University of Alberta has shown that new medications based on resveratrol—a compound found in red wine and nuts—may be used to treat a common heart-rhythm problem known as atrial fibrillation.
Faculty of Medicine & Dentistry researcher Peter Light and his colleagues recently published their findings in the peer-reviewed journal, British Journal of Pharmacology. They discovered that new resveratrol-based drugs they created that were used in the lab, helped regulate electrical activity in the heart by inhibiting irregular electrical currents, and by reducing the length of abnormal heart-rhythm episodes. These new medications they created targeted multiple activities in the cell, whereas current medications for heart rhythm problems target just one or two specific areas.
The U of A team is now working on advancing their drug design with colleagues at the Centre for Drug Research and Development, and via TEC Edmonton. Light expects that clinical trials with the advanced drug design will start within the next three to five years.
"We are at the next stage of developing a new oral medication for atrial fibrillation that patients could take on a daily basis to prevent this condition from occurring," says Light. "We are improving the medication's solubility, absorption, how it is metabolized and how long it stays in the blood stream."
Few medications are currently on the market to help treat atrial fibrillation effectively and those medications may have many serious side effects. Because resveratrol is a natural product, Light and his colleagues hope the new drug would be better tolerated by the body.
It has long been known that resveratrol has cardio-protective effects and seems to prevent some rhythm disorders of the heart, lowers blood pressure and reduces enlargement of the heart.
"We have had a tremendous amount of success with resveratrol and have been at the leading edge of resveratrol research as it relates to cardiovascular disease so the transition to making new and improved medications based on resveratrol derivatives is a logical next step," says Jason Dyck, one of the researchers on the team.
Atrial fibrillation is the most common abnormal heart rhythm problem affecting 1 in 200 people. It carries a five-fold increased risk of stroke, as well as an increased risk of heart failure and death.
Explore further: Higher risk of stroke from common heart disease
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An international research team led by medical scientists at the University of Alberta has shown that new medications based on resveratrol—a compound found in red wine and nuts—may be used to treat a common heart-rhythm problem known as atrial fibrillation.
Faculty of Medicine & Dentistry researcher Peter Light and his colleagues recently published their findings in the peer-reviewed journal, British Journal of Pharmacology. They discovered that new resveratrol-based drugs they created that were used in the lab, helped regulate electrical activity in the heart by inhibiting irregular electrical currents, and by reducing the length of abnormal heart-rhythm episodes. These new medications they created targeted multiple activities in the cell, whereas current medications for heart rhythm problems target just one or two specific areas.
The U of A team is now working on advancing their drug design with colleagues at the Centre for Drug Research and Development, and via TEC Edmonton. Light expects that clinical trials with the advanced drug design will start within the next three to five years.
"We are at the next stage of developing a new oral medication for atrial fibrillation that patients could take on a daily basis to prevent this condition from occurring," says Light. "We are improving the medication's solubility, absorption, how it is metabolized and how long it stays in the blood stream."
Few medications are currently on the market to help treat atrial fibrillation effectively and those medications may have many serious side effects. Because resveratrol is a natural product, Light and his colleagues hope the new drug would be better tolerated by the body.
It has long been known that resveratrol has cardio-protective effects and seems to prevent some rhythm disorders of the heart, lowers blood pressure and reduces enlargement of the heart.
"We have had a tremendous amount of success with resveratrol and have been at the leading edge of resveratrol research as it relates to cardiovascular disease so the transition to making new and improved medications based on resveratrol derivatives is a logical next step," says Jason Dyck, one of the researchers on the team.
Atrial fibrillation is the most common abnormal heart rhythm problem affecting 1 in 200 people. It carries a five-fold increased risk of stroke, as well as an increased risk of heart failure and death.
Explore further: Higher risk of stroke from common heart disease
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A natural compound found in some fruits, nuts and red wine may enhance exercise training and performance, demonstrates newly published medical research from the University of Alberta.
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People with rheumatoid arthritis are at a greater risk of irregular heart rhythm (known as atrial fibrillation) and stroke compared with the general population, finds a study published in the British Medical Journal today. ...
The Medical Minute: Atrial Fibrillation -- What is It?
Oct 06, 2011
Atrial fibrillation (AF) is the most common heart rhythm disturbance in the United States and affects 2 to 4 million Americans. It is usually a disease of aging, however it can affect people of all ages -- 1 percent of people ...
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Feb 11, 2013
(Medical Xpress)—Australians are being warned of a higher risk of stroke caused by the nation's most common heart rhythm disorder, atrial fibrillation.
Reseachers develop new 3-D technology to treat atrial fibrillation
May 11, 2013
Researchers at the Intermountain Heart Institute at Intermountain Medical Center have developed a new 3-D technology that for the first time allows cardiologists the ability to see the precise source of atrial fibrillation ...
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Risk factors for MACE following noncardiac surgery for patients with coronary stents
2 hours ago
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Air pollution increases heart attacks, according to research presented at the Acute Cardiac Care Congress 2013 by Dr Savina Nodari from Brescia, Italy. The Acute Cardiac Care Congress 2013 is the annual meeting of the Acute ...
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Oct 03, 2013
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