The critical scientific issues in evaluating cancer and non-cancer effects of oral exposure to inorganic arsenic have been identified, according to a report published by the U.S. Environmental Protection Agency and the National Academy of Sciences.
(HealthDay)—The critical scientific issues in evaluating cancer and non-cancer effects of oral exposure to inorganic arsenic have been identified, according to a report published by the U.S. Environmental Protection Agency (EPA) and the National Academy of Sciences.
To assist the EPA in performing the toxicologic assessment of inorganic arsenic, Joseph H. Graziano, Ph.D., from the Columbia University Mailman School of Public Health in New York City, and colleagues conducted an assessment to evaluate the critical scientific issues relating to the cancer and non-cancer effects of oral exposure to inorganic arsenic, and offer recommendations on how these issues could be addressed.
The researchers note that the steps involved in the toxicologic assessment of arsenic include hazard identification, based on broad literature searches and screening processes that identify specific inorganic arsenic-related health effects. Further evaluation of the evidence and systematic reviews were conducted to support the toxicologic assessment. The EPA draft plan aimed to conduct mode-of-action analyses for end points that seemed to have causal associations with arsenic. Priority outcomes with evidence of a causal association included lung, skin, and bladder cancer, ischemic heart disease, and skin lesions. Based on literature searches, factors that could contribute to arsenic susceptibility were identified. In addition, dose-response analyses were recommended.
"This interim report addresses the first phase of the project by providing recommendations on key aspects of and controversies related to the performance of the hazard identification and dose-response analyses for inorganic arsenic," the authors write.
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The critical scientific issues in evaluating cancer and non-cancer effects of oral exposure to inorganic arsenic have been identified, according to a report published by the U.S. Environmental Protection Agency and the National Academy of Sciences.
(HealthDay)—The critical scientific issues in evaluating cancer and non-cancer effects of oral exposure to inorganic arsenic have been identified, according to a report published by the U.S. Environmental Protection Agency (EPA) and the National Academy of Sciences.
To assist the EPA in performing the toxicologic assessment of inorganic arsenic, Joseph H. Graziano, Ph.D., from the Columbia University Mailman School of Public Health in New York City, and colleagues conducted an assessment to evaluate the critical scientific issues relating to the cancer and non-cancer effects of oral exposure to inorganic arsenic, and offer recommendations on how these issues could be addressed.
The researchers note that the steps involved in the toxicologic assessment of arsenic include hazard identification, based on broad literature searches and screening processes that identify specific inorganic arsenic-related health effects. Further evaluation of the evidence and systematic reviews were conducted to support the toxicologic assessment. The EPA draft plan aimed to conduct mode-of-action analyses for end points that seemed to have causal associations with arsenic. Priority outcomes with evidence of a causal association included lung, skin, and bladder cancer, ischemic heart disease, and skin lesions. Based on literature searches, factors that could contribute to arsenic susceptibility were identified. In addition, dose-response analyses were recommended.
"This interim report addresses the first phase of the project by providing recommendations on key aspects of and controversies related to the performance of the hazard identification and dose-response analyses for inorganic arsenic," the authors write.
Explore further: Denmark warns against rice for children
More information: More Information
Copyright © 2013 HealthDay. All rights reserved.
Medical Xpress on facebook
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Denmark warns against rice for children
May 15, 2013
Denmark's Veterinary and Food Administration said Wednesday that parents should stop giving their children rice cakes and rice milk, saying the products contained unacceptable levels of inorganic arsenic.
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(HealthDay)—A coordinated approach is necessary for monitoring and regulating the arsenic content of foods, according to a viewpoint piece published online April 29 in JAMA Internal Medicine.
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Jul 25, 2012
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1 hour ago
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How well a woman recovers from a concussion may depend on that time of the month.
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Study finds gymnasts' face high exposure to flame retardants
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