(HealthDay)—For females with osteoporosis, the rate of adjacent-level vertebral fractures is relatively low, with reduced odds with bisphosphonate therapy, according to a study published in the Dec. 1 issue of Spine.
Bruce Frankel, M.D., from the Medical University of South Carolina in Charleston, and colleagues examined the risk of adjacent-level vertebral fractures in patients with osteoporosis using data from a large, randomized fracture intervention trial of alendronate treatment. Incident morphometric fracture rates were assessed for bisphosphonate-treated and bisphosphonate-naive patients (1,950 participants).
During a mean follow-up of 2.9 years, the researchers identified adjacent-level vertebral fractures in 3.4 percent of patients in the alendronate group and 7.4 percent of patients in the placebo group, with annual rates of 1.2 and 2.5 percent, respectively. The thoracolumbar region (T11, T12, and L1) seemed to be the most prone to new adjacent-level fractures. In univariate analysis, older age at randomization, lower bone mineral density, inactivity, and placebo therapy correlated significantly with adjacent-level fractures (P ≤ 0.05). The odds of adjacent-level fractures were decreased with bisphosphonate therapy and higher bone mineral density, and were increased with older age at randomization, in multivariate analysis (P ≤ 0.05).
"New vertebral fractures adjacent to prevalent fractures occurred relatively infrequently in this treatment trial of alendronate in females with osteoporosis, and were more common with older age at randomization, lower bone mineral density and placebo treatment," the authors write.
Relevant financial activities outside the submitted work were disclosed: consultancy, grants, patents, royalties.
Explore further: Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2013 HealthDay. All rights reserved.
Medical Xpress on facebook
Related Stories
Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
Nov 07, 2013
A recent prospective, randomized, placebo-controlled clinical trial reports that calcium and vitamin D supplementation improves bone density in a group of male veterans with epilepsy who were treated chronically with antiepileptic ...
Once-yearly zoledronic acid benefits men with osteoporosis
Nov 02, 2012
(HealthDay)—For men with osteoporosis, a once-yearly infusion with zoledronic acid is associated with fewer vertebral fractures and improved bone health compared with placebo, according to a study published ...
The deadly news about all osteoporotic fractures
Nov 27, 2013
It is well known that hip and vertebral fractures increase the risk of premature death. Until now, little has been known about the clinical impact of non-hip, non-vertebral fractures – so new Australian research showing ...
Not only bone density, but also quality of bone predicts fracture risk
Aug 05, 2013
In a study carried out at the University of Eastern Finland, bone histomorphometry and infrared spectroscopy revealed abnormal bone properties in children with vertebral fractures and in children after solid ...
Hong Kong study shows lower survival rates after second hip fractures
Dec 15, 2013
Research presented today at the 4th Asia-Pacific Osteoporosis Meeting showed that second hip fractures are more deadly than first hip fractures. Based in Hong Kong, the study evaluated the overall incidence of a second hip ...
Recommended for you
Bird flu subtype re-emerges in Hong Kong
7 hours ago
An elderly man has contracted a mild form of bird flu in the first case of its type for four years, Hong Kong officials said on Monday.
Evidence-based guidelines developed for disc herniation
Dec 26, 2013
(HealthDay)—Evidence-based clinical guidelines have been developed for management of lumbar disc herniation with radiculopathy; the guidelines have been published in the Jan. 1 issue of The Spine Journal.
Don't let migraines ruin your holidays
Dec 26, 2013
(HealthDay)—The holidays can challenge the estimated 30 million migraine sufferers in the United States as they try to deal with crowds, travel delays, stress and other potential headache triggers.
New drug candidates show promise for cure for Chagas disease
Dec 26, 2013
A team of researchers from Canada has developed a class of compounds which may help eradicate a neglected tropical disease that is currently hard to kill in its chronic form. The research was published ahead of print in Antimicrobial Ag ...
New MERS death raises Saudi toll to 57
Dec 26, 2013
Saudi health authorities announced Thursday a new MERS death, bringing to 57 the number of people killed by the coronavirus in the country with the most fatalities.
Hong Kong reports first H7N9 death
Dec 26, 2013
A Hong Kong man infected with the H7N9 strain of bird flu died on Thursday, the first such death in the city since the virus emerged there this month.
User comments
© Medical Xpress 2011-2013, Science X network
(HealthDay)—For females with osteoporosis, the rate of adjacent-level vertebral fractures is relatively low, with reduced odds with bisphosphonate therapy, according to a study published in the Dec. 1 issue of Spine.
Bruce Frankel, M.D., from the Medical University of South Carolina in Charleston, and colleagues examined the risk of adjacent-level vertebral fractures in patients with osteoporosis using data from a large, randomized fracture intervention trial of alendronate treatment. Incident morphometric fracture rates were assessed for bisphosphonate-treated and bisphosphonate-naive patients (1,950 participants).
During a mean follow-up of 2.9 years, the researchers identified adjacent-level vertebral fractures in 3.4 percent of patients in the alendronate group and 7.4 percent of patients in the placebo group, with annual rates of 1.2 and 2.5 percent, respectively. The thoracolumbar region (T11, T12, and L1) seemed to be the most prone to new adjacent-level fractures. In univariate analysis, older age at randomization, lower bone mineral density, inactivity, and placebo therapy correlated significantly with adjacent-level fractures (P ≤ 0.05). The odds of adjacent-level fractures were decreased with bisphosphonate therapy and higher bone mineral density, and were increased with older age at randomization, in multivariate analysis (P ≤ 0.05).
"New vertebral fractures adjacent to prevalent fractures occurred relatively infrequently in this treatment trial of alendronate in females with osteoporosis, and were more common with older age at randomization, lower bone mineral density and placebo treatment," the authors write.
Relevant financial activities outside the submitted work were disclosed: consultancy, grants, patents, royalties.
Explore further: Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2013 HealthDay. All rights reserved.
Medical Xpress on facebook
Related Stories
Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
Nov 07, 2013
A recent prospective, randomized, placebo-controlled clinical trial reports that calcium and vitamin D supplementation improves bone density in a group of male veterans with epilepsy who were treated chronically with antiepileptic ...
Once-yearly zoledronic acid benefits men with osteoporosis
Nov 02, 2012
(HealthDay)—For men with osteoporosis, a once-yearly infusion with zoledronic acid is associated with fewer vertebral fractures and improved bone health compared with placebo, according to a study published ...
The deadly news about all osteoporotic fractures
Nov 27, 2013
It is well known that hip and vertebral fractures increase the risk of premature death. Until now, little has been known about the clinical impact of non-hip, non-vertebral fractures – so new Australian research showing ...
Not only bone density, but also quality of bone predicts fracture risk
Aug 05, 2013
In a study carried out at the University of Eastern Finland, bone histomorphometry and infrared spectroscopy revealed abnormal bone properties in children with vertebral fractures and in children after solid ...
Hong Kong study shows lower survival rates after second hip fractures
Dec 15, 2013
Research presented today at the 4th Asia-Pacific Osteoporosis Meeting showed that second hip fractures are more deadly than first hip fractures. Based in Hong Kong, the study evaluated the overall incidence of a second hip ...
Recommended for you
Bird flu subtype re-emerges in Hong Kong
7 hours ago
An elderly man has contracted a mild form of bird flu in the first case of its type for four years, Hong Kong officials said on Monday.
Evidence-based guidelines developed for disc herniation
Dec 26, 2013
(HealthDay)—Evidence-based clinical guidelines have been developed for management of lumbar disc herniation with radiculopathy; the guidelines have been published in the Jan. 1 issue of The Spine Journal.
Don't let migraines ruin your holidays
Dec 26, 2013
(HealthDay)—The holidays can challenge the estimated 30 million migraine sufferers in the United States as they try to deal with crowds, travel delays, stress and other potential headache triggers.
New drug candidates show promise for cure for Chagas disease
Dec 26, 2013
A team of researchers from Canada has developed a class of compounds which may help eradicate a neglected tropical disease that is currently hard to kill in its chronic form. The research was published ahead of print in Antimicrobial Ag ...
New MERS death raises Saudi toll to 57
Dec 26, 2013
Saudi health authorities announced Thursday a new MERS death, bringing to 57 the number of people killed by the coronavirus in the country with the most fatalities.
Hong Kong reports first H7N9 death
Dec 26, 2013
A Hong Kong man infected with the H7N9 strain of bird flu died on Thursday, the first such death in the city since the virus emerged there this month.
User comments
© Medical Xpress 2011-2013, Science X network
0 comments:
Post a Comment