(HealthDay)—Detection of human papillomavirus (HPV) 6, 11, 42 or combination infections does not identify increased three-year risk of cervical precancer, according to a study published in the January issue of Obstetrics & Gynecology.
Philip E. Castle, Ph.D., M.P.H., from the Albert Einstein College of Medicine in New York City, and colleagues used data from the New Mexico Human Papillomavirus Pap Registry for a stratified sample of 59,644 residual cervical cytology specimens that underwent HPV genotyping from a population of 379,000 cytology specimens. The three-year cumulative incidence of cervical intraepithelial neoplasia grade 2 or more severe (CIN 2+) and grade 3 or more severe (CIN 3+) was assessed after detection of 581 single or multiple infections of HPV 6, 11, or 42.
The researchers found that there was a 0.8 percent overall prevalence of a single infection of HPV 6, 11, or 42. After 581 HPV 6, 11, 42, or combinations infections, the three-year risk of CIN 2+ and CIN 3+ were 0.4 and 0.0 percent, respectively. In comparison, after a negative HPV result (27,522 cytologic results), the three-year risks of CIN 2+ and CIN 3+ were 0.2 and 0.1 percent, respectively.
"Testing for HPV 6, 11, 42, or combinations of those types should be discontinued because it has no proven benefit to patients," the authors write.
Roche Molecular Systems provided the Genotyping Test and equipment to automate the HPV genotyping assays. Two authors disclosed financial ties to pharmaceutical and biotechnology companies, including Roche.
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(HealthDay)—Detection of human papillomavirus (HPV) 6, 11, 42 or combination infections does not identify increased three-year risk of cervical precancer, according to a study published in the January issue of Obstetrics & Gynecology.
Philip E. Castle, Ph.D., M.P.H., from the Albert Einstein College of Medicine in New York City, and colleagues used data from the New Mexico Human Papillomavirus Pap Registry for a stratified sample of 59,644 residual cervical cytology specimens that underwent HPV genotyping from a population of 379,000 cytology specimens. The three-year cumulative incidence of cervical intraepithelial neoplasia grade 2 or more severe (CIN 2+) and grade 3 or more severe (CIN 3+) was assessed after detection of 581 single or multiple infections of HPV 6, 11, or 42.
The researchers found that there was a 0.8 percent overall prevalence of a single infection of HPV 6, 11, or 42. After 581 HPV 6, 11, 42, or combinations infections, the three-year risk of CIN 2+ and CIN 3+ were 0.4 and 0.0 percent, respectively. In comparison, after a negative HPV result (27,522 cytologic results), the three-year risks of CIN 2+ and CIN 3+ were 0.2 and 0.1 percent, respectively.
"Testing for HPV 6, 11, 42, or combinations of those types should be discontinued because it has no proven benefit to patients," the authors write.
Roche Molecular Systems provided the Genotyping Test and equipment to automate the HPV genotyping assays. Two authors disclosed financial ties to pharmaceutical and biotechnology companies, including Roche.
Explore further: Multiple strategies are more efficient for cervical cancer
More information: Full Text (subscription or payment may be required)
Copyright © 2013 HealthDay. All rights reserved.
Medical Xpress on facebook
Related Stories
Multiple strategies are more efficient for cervical cancer
Mar 30, 2013
(HealthDay)—Multiple cervical cancer screening strategies that maximize early detection of high-grade disease without excessive increases in initial testing appear to be most effective, according to a study ...
HPV testing followed by cytology and repeat HPV testing may improve cervical cancer screening
Jan 13, 2009
The use of human papillomavirus (HPV) DNA testing as an initial screening step followed by triage with a standard Pap test (cytology) and repeat HPV DNA testing may increase the accuracy of cervical cancer screening, according ...
Study: Benefit of HPV Vaccination, Frequent Screening for Women over 41 is Likely to be Low
Feb 15, 2010
The overall potential benefits of human papillomavirus (HPV) vaccinations or frequent HPV screenings for women over the age of 41 are low, concludes a new study published online February 15 in the Journal of the National Ca ...
Cheaper and more effective test available for women following pre-cervical cancer treatment
Nov 01, 2012
Testing women to see if they are cured of HPV (the virus that can cause genital warts and cervical cancer) following treatment for abnormal cells on the surface of the cervix is more effective and cheaper than cytology testing ...
HPV test detects more pre-cancerous cells than conventional smear test
Apr 27, 2010
Human papillomavirus (HPV) screening detects more cervical severe pre-cancerous lesions than conventional cervical screening, finds a study published in the British Medical Journal today.
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Dec 23, 2013
(HealthDay)—Women bothered by hot flashes or other effects of menopause have a number of treatment options—hormonal or not, according to updated guidelines from the American College of Obstetricians and ...
Women's perceptions of 'normal' female genitalia may be influenced by exposure to modified images
Dec 20, 2013
Women's perceptions of what is considered normal and desirable female genitalia may be influenced by exposure to modified images, suggests a new study published today (20 December) in BJOG: An International Journal of Ob ...
Maternal vitamin D tied to risk of small for gestational age
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(HealthDay)—Maternal serum 25-hydroxyvitamin D concentration is associated with the risk of small-for-gestational-age (SGA) offspring, according to a study published online Dec. 6 in Obstetrics & Gynecology.
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User comments
© Medical Xpress 2011-2013, Science X network
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