by Charles Feigenoff
U.Va. assistant professor of biomedical engineering Kevin Janes uses his expertise in computational modeling in his research of tumors.
When Kevin Janes considers a tumor, he imagines the population of a dark and dystopian city. Originally colonized by the descendants of a single malignant cell, the tumor grows more diverse over time, as its inhabitants recruit different types of cells to join them and its cell of origin begins to evolve under the pressure of natural selection.
"Seen in this light, treating a tumor is like managing a volatile and unruly mob," said Janes, a University of Virginia assistant professor of biomedical engineering. "Some of the cells may be truly bad actors, while others are swept along by circumstances."
Janes has found just such a group. He has demonstrated that some cells found in breast cancer are not always malignant, but are affected by their relationship to the extracellular matrix that surrounds them. Depending on the signals that pass between them and the matrix, the cells grow and migrate uncontrollably or act like normal cells. They exist in two very different states.
"If you're uniformly aggressive, that mob of cancer cells could fragment and become even more dangerous," he said. "A more productive therapeutic approach might be to consider the tumor ecology."
Janes advocates focusing on those cells that change their state depending on the surrounding environment and finding ways to steer them to a more benign state or one that might be more susceptible to existing treatments.
The design of this experiment reflects Janes's expertise as a computational modeler. His goal in this case was to steer a middle course between creating a generalized atlas of the tumor and creating a census of individual cells, which would be both time-consuming and impractical. "We want to come at this problem with just the degree of specificity needed to highlight the heterogeneity and variability of cells within a tumor," he said.
Guided by his models, Janes adopted a strategy of measuring all the genes expressed in small samples taken at different locations across a tumor. "The technique is designed to identify states that recur with reasonable frequency," he said. "The models gave us an understanding of the sample size we needed to produce reliable results." Janes also uses computational analysis to extract as much information as possible from his experimental data.
This computational work, Janes said, builds on modes of thought he brings to the problem as an engineer. "Engineering is the art and science of making effective compromises," he said. "We start with an end goal, and we identify the approximations that will enable us to approach this goal. As an engineer, I would rather arrive at a good-enough answer today than a perfect answer never."
Moving forward, Janes hopes to test his findings about breast cancer cells in a therapeutic context. "We think we have found a protein that triggers these state changes," he said. "Using this knowledge, we would like to see if we can move these cells to a more tractable state where they would be less invasive. Long-term tumor stasis would be a worthwhile goal."
Janes would also like to migrate his studies directly to clinical specimens of breast tumors. "We used three-dimensional tissue cultures to demonstrate proof of concept," he said. "We now have the confidence to make the leap directly to clinical samples." Janes would like to analyze a subset of breast cancers, catalog the states observed and determine if the inventory of states or the proportion of states change from less advanced to more advanced tumors.
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© Medical Xpress 2011-2014, Science X network
by Charles Feigenoff
U.Va. assistant professor of biomedical engineering Kevin Janes uses his expertise in computational modeling in his research of tumors.
When Kevin Janes considers a tumor, he imagines the population of a dark and dystopian city. Originally colonized by the descendants of a single malignant cell, the tumor grows more diverse over time, as its inhabitants recruit different types of cells to join them and its cell of origin begins to evolve under the pressure of natural selection.
"Seen in this light, treating a tumor is like managing a volatile and unruly mob," said Janes, a University of Virginia assistant professor of biomedical engineering. "Some of the cells may be truly bad actors, while others are swept along by circumstances."
Janes has found just such a group. He has demonstrated that some cells found in breast cancer are not always malignant, but are affected by their relationship to the extracellular matrix that surrounds them. Depending on the signals that pass between them and the matrix, the cells grow and migrate uncontrollably or act like normal cells. They exist in two very different states.
"If you're uniformly aggressive, that mob of cancer cells could fragment and become even more dangerous," he said. "A more productive therapeutic approach might be to consider the tumor ecology."
Janes advocates focusing on those cells that change their state depending on the surrounding environment and finding ways to steer them to a more benign state or one that might be more susceptible to existing treatments.
The design of this experiment reflects Janes's expertise as a computational modeler. His goal in this case was to steer a middle course between creating a generalized atlas of the tumor and creating a census of individual cells, which would be both time-consuming and impractical. "We want to come at this problem with just the degree of specificity needed to highlight the heterogeneity and variability of cells within a tumor," he said.
Guided by his models, Janes adopted a strategy of measuring all the genes expressed in small samples taken at different locations across a tumor. "The technique is designed to identify states that recur with reasonable frequency," he said. "The models gave us an understanding of the sample size we needed to produce reliable results." Janes also uses computational analysis to extract as much information as possible from his experimental data.
This computational work, Janes said, builds on modes of thought he brings to the problem as an engineer. "Engineering is the art and science of making effective compromises," he said. "We start with an end goal, and we identify the approximations that will enable us to approach this goal. As an engineer, I would rather arrive at a good-enough answer today than a perfect answer never."
Moving forward, Janes hopes to test his findings about breast cancer cells in a therapeutic context. "We think we have found a protein that triggers these state changes," he said. "Using this knowledge, we would like to see if we can move these cells to a more tractable state where they would be less invasive. Long-term tumor stasis would be a worthwhile goal."
Janes would also like to migrate his studies directly to clinical specimens of breast tumors. "We used three-dimensional tissue cultures to demonstrate proof of concept," he said. "We now have the confidence to make the leap directly to clinical samples." Janes would like to analyze a subset of breast cancers, catalog the states observed and determine if the inventory of states or the proportion of states change from less advanced to more advanced tumors.
Explore further: Stopping the spread of breast cancer
Medical Xpress on facebook
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23 hours ago
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Jan 23, 2014
Cancer isn't a singular disease, even when talking about one tumor. A tumor consists of a varied mix of cells whose complicated arrangement changes all the time, especially and most vexingly as doctors and ...
Genetically engineered MSCs kill metastatic lung cancer cells in mice
May 19, 2009
Researchers in London have demonstrated the ability of adult stem cells from bone marrow (mesenchymal stem cells, or MSCs) to deliver a cancer-killing protein to tumors.
New tool to grow cancer cells streamlines laboratory research
May 15, 2014
A new technique that allows the growth of both normal and cancer cells and keeps them alive indefinitely is transforming and expediting basic cancer research, say investigators from Georgetown Lombardi Comprehensive ...
Breast cancer cell subpopulation cooperation can spur tumor growth
Apr 08, 2014
Subpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations ...
Recommended for you
Four new genes confirmed to increase familial breast cancer risk
8 minutes ago
Four new genes have been added to the growing list of those known to cause increased breast cancer risk when mutated through the efforts of researchers at Huntsman Cancer Institute (HCI) at the University ...
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2 hours ago
(Medical Xpress)—Not everyone with cancer can be a media hero battling the odds with a feisty survival story, says a Massey researcher. Dr Colette Nixon studied the impact of therapy provided by a unique ...
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17 hours ago
Researchers at the University of Illinois at Chicago are conducting a clinical trial to evaluate a new, three-drug combination therapy for advanced pancreatic cancer.
New test predicts if breast cancer will spread
18 hours ago
The study was led by researchers at the National Cancer Institute (NCI)—designated Albert Einstein Cancer Center of Albert Einstein College of Medicine of Yeshiva University and Montefiore Einstein Center ...
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18 hours ago
(HealthDay)—Regular exercise and a diet that includes fish may help colon cancer patients improve their odds of avoiding a relapse, a new study suggests.
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User comments
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