Here's more evidence that pregnant women should be careful about what they eat and drink: A new research report appearing in the June 2014 issue of The FASEB Journal shows that when taken during pregnancy, resveratrol supplements led to developmental abnormalities in the fetal pancreas. This study has direct relevance to human health—Resveratrol is widely used for its recognized health benefits, and is readily available over the counter.
"The important message in this study is that women should be very careful about what they consume while pregnant, and they should not take supplements, like Resveratrol, without consulting with their doctors," said Kevin L. Grove, Ph.D., a researcher involved in the work from the Division of Diabetes, Obesity and Metabolism and the Division of Reproductive and Development Science at Oregon Health and Science University in Portland, Oregon. "What might be good for the mother may not be good for the baby."
To make this discovery, Grove and colleagues administered Resveratrol supplements every day throughout pregnancy to obese female macaque monkeys consuming a Western diet. A second group of obese monkeys were not given the supplement, and all comparisons were made against lean monkeys fed a healthy low fat diet. The animals were closely monitored for health complications and blood flow through the placenta was determined by ultra sound. The fetuses were analyzed for developmental abnormalities, and findings showed definitive evidence of pancreatic abnormalities.
"We've known for a long time that resveratrol is pharmacologically active, and we're just now really beginning to understand the pros and cons of consuming high concentrations of this substance," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "As we begin to establish a safety profile for resveratrol and other dietary supplements, findings like this should come as no surprise. There are always negative side effects when you eat, drink, take or do too much of anything."
Explore further: Diets rich in antioxidant resveratrol fail to reduce deaths, heart disease or cancer
More information: Victoria H. J. Roberts, Lynley D. Pound, Stephanie R. Thorn, Melanie B. Gillingham, Kent L. Thornburg, Jacob E. Friedman, Antonio E. Frias, and Kevin L. Grove. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. June 2014 28:2466-2477; DOI: 10.1096/fj.13-245472
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Here's more evidence that pregnant women should be careful about what they eat and drink: A new research report appearing in the June 2014 issue of The FASEB Journal shows that when taken during pregnancy, resveratrol supplements led to developmental abnormalities in the fetal pancreas. This study has direct relevance to human health—Resveratrol is widely used for its recognized health benefits, and is readily available over the counter.
"The important message in this study is that women should be very careful about what they consume while pregnant, and they should not take supplements, like Resveratrol, without consulting with their doctors," said Kevin L. Grove, Ph.D., a researcher involved in the work from the Division of Diabetes, Obesity and Metabolism and the Division of Reproductive and Development Science at Oregon Health and Science University in Portland, Oregon. "What might be good for the mother may not be good for the baby."
To make this discovery, Grove and colleagues administered Resveratrol supplements every day throughout pregnancy to obese female macaque monkeys consuming a Western diet. A second group of obese monkeys were not given the supplement, and all comparisons were made against lean monkeys fed a healthy low fat diet. The animals were closely monitored for health complications and blood flow through the placenta was determined by ultra sound. The fetuses were analyzed for developmental abnormalities, and findings showed definitive evidence of pancreatic abnormalities.
"We've known for a long time that resveratrol is pharmacologically active, and we're just now really beginning to understand the pros and cons of consuming high concentrations of this substance," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "As we begin to establish a safety profile for resveratrol and other dietary supplements, findings like this should come as no surprise. There are always negative side effects when you eat, drink, take or do too much of anything."
Explore further: Diets rich in antioxidant resveratrol fail to reduce deaths, heart disease or cancer
More information: Victoria H. J. Roberts, Lynley D. Pound, Stephanie R. Thorn, Melanie B. Gillingham, Kent L. Thornburg, Jacob E. Friedman, Antonio E. Frias, and Kevin L. Grove. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. June 2014 28:2466-2477; DOI: 10.1096/fj.13-245472
Medical Xpress on facebook
Related Stories
Diets rich in antioxidant resveratrol fail to reduce deaths, heart disease or cancer
May 12, 2014
A study of Italians who consume a diet rich in resveratrol—the compound found in red wine, dark chocolate and berries—finds they live no longer than and are just as likely to develop cardiovascular disease ...
Red wine ingredient resveratrol stops breast cancer growth
Sep 29, 2011
Cheers! A new research report appearing in the October 2011 issue of The FASEB Journal shows that resveratrol, the "healthy" ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of est ...
First clinical trial of red wine ingredient shows metabolic shifts
Nov 01, 2011
When obese men take a relatively small dose of resveratrol in purified form every day for a month, their metabolisms change for the better. In fact, the effects appear to be as good for us as severe calorie restriction. Resveratrol ...
Red wine: Exercise in a bottle?
Jun 30, 2011
As strange as it sounds, a new research study published in the FASEB Journal, suggests that the "healthy" ingredient in red wine, resveratrol, may prevent the negative effects that spaceflight and sedentary lifestyles have o ...
Scientists reveal molecular secrets behind resveratrol's health benefits
Apr 29, 2014
Resveratrol has been much in the news as the component of grapes and red wine associated with reducing "bad cholesterol," heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, ...
Recommended for you
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