A team of Johns Hopkins specialists, using a battery of imaging and cognitive tests, has gathered evidence of accumulated brain damage that could be linked to specific memory deficits in former National Football League (NFL) players experienced decades after they stopped playing the game.
Results of the small study of nine men provide further evidence for potential long-term neurological risk to football players who sustain repeated concussions and support calls for better player protections.
"We're hoping that our findings are going to further inform the game," says Jennifer Coughlin, M.D., assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. "That may mean individuals are able to make more educated decisions about whether they're susceptible to brain injury, advise how helmets are structured or inform guidelines for the game to better protect players."
Several anecdotal accounts and studies have suggested that athletes, such as collegiate and professional football, hockey, and soccer players, exposed to repeat concussions could suffer permanent brain damage and deficits from these events. However, the mechanism of damage and the source of these deficits have been unclear.
To reveal them, Coughlin; Yuchuan Wang, Ph.D., assistant professor of radiology and radiological science at the Johns Hopkins University School of Medicine; and their colleagues used tests to directly detect deficits and to quantify localized molecular differences between the brains of former players and healthy people who didn't play football.
The researchers recruited nine former NFL players who retired decades ago and ranged in age from 57 to 74. The men had played a variety of team positions and had a wide range of self-reported, historical concussions, varying from none for a running back to 40 for a defensive tackle. The researchers also recruited nine age-matched "controls"—healthy individuals who had no reason to suspect they had brain injuries.
Each of the volunteers underwent a positron emission tomography (PET) scan, a test in which an injected radioactive chemical binds to a specific biological molecule, allowing researchers to physically see and measure its presence throughout the body. In this case, the research team focused on the translocator protein, which signals the degree of damage and repair in the brain. While healthy individuals have low levels of this protein spread throughout the brain, those with brain injuries tend to have concentrated zones with high levels of translocator protein wherever an injury has occurred.
The volunteers also underwent MRIs, which allowed the researchers to match up the PET scan findings with anatomical locations in the volunteers' brains and check for structural abnormalities. In addition, they took a battery of memory tests.
While the control volunteers' tests showed no evidence of brain damage, PET scans showed that on average, the group of former NFL players had evidence of brain injury in several temporal medial lobe regions, including the amygdala, a region that plays a significant role in regulating mood. Imaging also identified injuries in many players' supramarginal gyrus, an area linked to verbal memory.
While the hippocampus, an area that plays a role in several aspects of memory, didn't show evidence of damage in the PET scans, MRIs of the former players' brains showed atrophy of the right-side hippocampus, suggesting that this region may have shrunk in size due to previous damage.
Additionally, many of the NFL players scored low on memory testing, particularly in tests of verbal learning and memory.
Though the researchers emphasize that this pilot study, published in the February 2015 issue of the journal Neurobiology of Disease, is small in size, they say that the evidence among just nine former NFL players suggests that there are molecular and structural changes in specific brain regions of athletes who have a history of repetitive hits to the head, even many years after they've left active play.
The researchers are currently looking for translocator protein hotspots in both active and recently retired players to help determine whether these changes develop close to the time of play or whether they're a result of a more delayed response to injury with similarities to other degenerative brain disorders.
If these findings are seen in studies with larger numbers of participants, they say, use of this molecular brain imaging technique could eventually lead to changes in the way players are treated after experiencing concussion or how contact sports are played.
Explore further: Brain-injury program working with NFL players
Medical Xpress on facebook
Related Stories
Brain-injury program working with NFL players
Dec 16, 2014
A brain-injury treatment program originally designed for military veterans injured on the battlefield has been updated to include professional athletes.
Chronic brain damage not as prevalent in NFL players, say researchers
Jun 25, 2014
A study published online today in Sports Health: A Multidisciplinary Approach provides a different take on previous information regarding the prevalence of chronic brain damage in retired NFL players.
Football players found to have brain damage from mild 'unreported' concussions
Nov 24, 2014
A new, enhanced MRI diagnostic approach was, for the first time, able to identify significant damage to the blood-brain barrier (BBB) of professional football players following "unreported" trauma or mild ...
Middle school football doesn't seem to cause short-term brain damage: study
Jan 09, 2015
(HealthDay)—Children who play football in middle school don't appear to have any noticeable short-term brain damage from repeated hits to the head, new research suggests.
Difference found in brain area linked to memory among college football players
May 13, 2014
Preliminary research finds that within a group of collegiate football players, those who experienced a concussion or had been playing for more years had smaller hippocampal volume (an area of the brain important for memory) ...
Recommended for you
Gov't to overhaul Medicare payments to doctors, hospitals
1 hour ago
The Obama administration Monday announced a plan to shift Medicare payments it makes to hospitals and doctors so they reward quality over volume. Officials said they hoped the move would be a catalyst for the entire health-care ...
Good bedtime habits equal better sleep for kids
1 hour ago
Children obtain better and more age-appropriate sleep in the presence of household rules and regular sleep-wake routines, according to sleep researchers.
Even with copayments for nonurgent care, Medicaid patients still rely on ERs
3 hours ago
How can states and federal government provide adequate health care to poor people, without overburdening taxpayers or leaving health care providers with billions in unpaid bills? That thorny problem is especially challenging ...
Poor psychosocial work environments may contribute to heart problems
3 hours ago
A psychosocially poor work environment means that employees experience highly demanding requirements but have little ability to control their work or not feel sufficiently appreciated for the contributions they make.
Ethnic minorities and deprived communities hardest hit by air pollution
4 hours ago
Air pollution levels are linked to many forms of ill health, including higher risk of respiratory and cardiovascular diseases, especially for more vulnerable groups such as children and the elderly.
Naughty food photos attract more attention
4 hours ago
Researchers have discovered a quirk in how we pay attention to food.
User comments
Please sign in to add a comment. Registration is free, and takes less than a minute. Read more
Click here to reset your password.
Sign in to get notified via email when new comments are made.
© Medical Xpress 2011-2014, Science X network
A team of Johns Hopkins specialists, using a battery of imaging and cognitive tests, has gathered evidence of accumulated brain damage that could be linked to specific memory deficits in former National Football League (NFL) players experienced decades after they stopped playing the game.
Results of the small study of nine men provide further evidence for potential long-term neurological risk to football players who sustain repeated concussions and support calls for better player protections.
"We're hoping that our findings are going to further inform the game," says Jennifer Coughlin, M.D., assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. "That may mean individuals are able to make more educated decisions about whether they're susceptible to brain injury, advise how helmets are structured or inform guidelines for the game to better protect players."
Several anecdotal accounts and studies have suggested that athletes, such as collegiate and professional football, hockey, and soccer players, exposed to repeat concussions could suffer permanent brain damage and deficits from these events. However, the mechanism of damage and the source of these deficits have been unclear.
To reveal them, Coughlin; Yuchuan Wang, Ph.D., assistant professor of radiology and radiological science at the Johns Hopkins University School of Medicine; and their colleagues used tests to directly detect deficits and to quantify localized molecular differences between the brains of former players and healthy people who didn't play football.
The researchers recruited nine former NFL players who retired decades ago and ranged in age from 57 to 74. The men had played a variety of team positions and had a wide range of self-reported, historical concussions, varying from none for a running back to 40 for a defensive tackle. The researchers also recruited nine age-matched "controls"—healthy individuals who had no reason to suspect they had brain injuries.
Each of the volunteers underwent a positron emission tomography (PET) scan, a test in which an injected radioactive chemical binds to a specific biological molecule, allowing researchers to physically see and measure its presence throughout the body. In this case, the research team focused on the translocator protein, which signals the degree of damage and repair in the brain. While healthy individuals have low levels of this protein spread throughout the brain, those with brain injuries tend to have concentrated zones with high levels of translocator protein wherever an injury has occurred.
The volunteers also underwent MRIs, which allowed the researchers to match up the PET scan findings with anatomical locations in the volunteers' brains and check for structural abnormalities. In addition, they took a battery of memory tests.
While the control volunteers' tests showed no evidence of brain damage, PET scans showed that on average, the group of former NFL players had evidence of brain injury in several temporal medial lobe regions, including the amygdala, a region that plays a significant role in regulating mood. Imaging also identified injuries in many players' supramarginal gyrus, an area linked to verbal memory.
While the hippocampus, an area that plays a role in several aspects of memory, didn't show evidence of damage in the PET scans, MRIs of the former players' brains showed atrophy of the right-side hippocampus, suggesting that this region may have shrunk in size due to previous damage.
Additionally, many of the NFL players scored low on memory testing, particularly in tests of verbal learning and memory.
Though the researchers emphasize that this pilot study, published in the February 2015 issue of the journal Neurobiology of Disease, is small in size, they say that the evidence among just nine former NFL players suggests that there are molecular and structural changes in specific brain regions of athletes who have a history of repetitive hits to the head, even many years after they've left active play.
The researchers are currently looking for translocator protein hotspots in both active and recently retired players to help determine whether these changes develop close to the time of play or whether they're a result of a more delayed response to injury with similarities to other degenerative brain disorders.
If these findings are seen in studies with larger numbers of participants, they say, use of this molecular brain imaging technique could eventually lead to changes in the way players are treated after experiencing concussion or how contact sports are played.
Explore further: Brain-injury program working with NFL players
Medical Xpress on facebook
Related Stories
Brain-injury program working with NFL players
Dec 16, 2014
A brain-injury treatment program originally designed for military veterans injured on the battlefield has been updated to include professional athletes.
Chronic brain damage not as prevalent in NFL players, say researchers
Jun 25, 2014
A study published online today in Sports Health: A Multidisciplinary Approach provides a different take on previous information regarding the prevalence of chronic brain damage in retired NFL players.
Football players found to have brain damage from mild 'unreported' concussions
Nov 24, 2014
A new, enhanced MRI diagnostic approach was, for the first time, able to identify significant damage to the blood-brain barrier (BBB) of professional football players following "unreported" trauma or mild ...
Middle school football doesn't seem to cause short-term brain damage: study
Jan 09, 2015
(HealthDay)—Children who play football in middle school don't appear to have any noticeable short-term brain damage from repeated hits to the head, new research suggests.
Difference found in brain area linked to memory among college football players
May 13, 2014
Preliminary research finds that within a group of collegiate football players, those who experienced a concussion or had been playing for more years had smaller hippocampal volume (an area of the brain important for memory) ...
Recommended for you
Gov't to overhaul Medicare payments to doctors, hospitals
1 hour ago
The Obama administration Monday announced a plan to shift Medicare payments it makes to hospitals and doctors so they reward quality over volume. Officials said they hoped the move would be a catalyst for the entire health-care ...
Good bedtime habits equal better sleep for kids
1 hour ago
Children obtain better and more age-appropriate sleep in the presence of household rules and regular sleep-wake routines, according to sleep researchers.
Even with copayments for nonurgent care, Medicaid patients still rely on ERs
3 hours ago
How can states and federal government provide adequate health care to poor people, without overburdening taxpayers or leaving health care providers with billions in unpaid bills? That thorny problem is especially challenging ...
Poor psychosocial work environments may contribute to heart problems
3 hours ago
A psychosocially poor work environment means that employees experience highly demanding requirements but have little ability to control their work or not feel sufficiently appreciated for the contributions they make.
Ethnic minorities and deprived communities hardest hit by air pollution
4 hours ago
Air pollution levels are linked to many forms of ill health, including higher risk of respiratory and cardiovascular diseases, especially for more vulnerable groups such as children and the elderly.
Naughty food photos attract more attention
4 hours ago
Researchers have discovered a quirk in how we pay attention to food.
User comments
Please sign in to add a comment. Registration is free, and takes less than a minute. Read more
Click here
to reset your password.
Sign in to get notified via email when new comments are made.
© Medical Xpress 2011-2014, Science X network
0 comments:
Post a Comment