(HealthDay)—Botulinum toxin-A (BTX-A) appears to be beneficial for painful diabetic neuropathy (PDN), according to a meta-analysis published online March 20 in Pain Medicine.
Shaheen E. Lakhan, M.D., Ph.D., from the Global Neuroscience Initiative Foundation in Los Angeles, and colleagues conducted a meta-analysis of two studies using BTX-A in the treatment of neuropathic pain. The difference in visual analog scale (VAS) from pre-intervention to one month post-intervention was measured as the primary outcome.
The researchers found that following treatment with BTX-A there was an improvement of 1.96 VAS points (P < 0.001), which corresponded to a clinically significant improvement of "minimum change in pain." There was no statistically significant effect on adverse events in terms of infection at injection site (P = 0.49).
"Tests for significance, low overall risk of bias, and almost no statistical heterogeneity suggests that there is a correlation between BTX-A and improvement of pain scores in PDN," the authors write.
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(HealthDay)—Botulinum toxin-A (BTX-A) appears to be beneficial for painful diabetic neuropathy (PDN), according to a meta-analysis published online March 20 in Pain Medicine.
Shaheen E. Lakhan, M.D., Ph.D., from the Global Neuroscience Initiative Foundation in Los Angeles, and colleagues conducted a meta-analysis of two studies using BTX-A in the treatment of neuropathic pain. The difference in visual analog scale (VAS) from pre-intervention to one month post-intervention was measured as the primary outcome.
The researchers found that following treatment with BTX-A there was an improvement of 1.96 VAS points (P < 0.001), which corresponded to a clinically significant improvement of "minimum change in pain." There was no statistically significant effect on adverse events in terms of infection at injection site (P = 0.49).
"Tests for significance, low overall risk of bias, and almost no statistical heterogeneity suggests that there is a correlation between BTX-A and improvement of pain scores in PDN," the authors write.
Explore further: Pre-op back pain, pain sensitivity predict outcomes
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2015 HealthDay. All rights reserved.
Medical Xpress on facebook
Related Stories
Pre-op back pain, pain sensitivity predict outcomes
(HealthDay)—Preoperative back pain and individual pain sensitivity can predict postoperative pain following lumbar surgery, according to a study published in the December issue of Pain Medicine.
Earlier surgery tied to greater benefit in cervical radiculopathy
(HealthDay)—For patients with painful degenerative disc disease and radiculopathy, undergoing anterior cervical discectomy and fusion (ACDF) surgery within six months of becoming symptomatic is associated ...
Depression influences post-op satisfaction in older patients
(HealthDay)—For older patients undergoing revision lumbar surgery, preoperative depression influences patient satisfaction two years after surgery, according to research published in the Sept. 1 issue of ...
Patients with severe back pain who quit smoking report less pain than patients who continue to smoke
For years, research has shown a link between smoking and an increased risk for low back pain, intervertebral (spine) disc disease, and inferior patient outcomes following surgery. A new study, published in the December 2012 ...
Relief for diabetics with painful condition
Walking barefoot on sand "felt like walking on glass" for Keith Wenckowski, who has lived with type-one diabetes for more than two decades.
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