(HealthDay)—For patients with papulopustular rosacea (PPR), once-daily ivermectin 1 percent cream (IVM 1 percent) is superior to twice-daily metronidazole (MTZ 0.75 percent) cream, according to a study published in the April issue of the British Journal of Dermatology.
Alain Taieb, M.D., Ph.D., from Hôpital Saint-André in Bordeaux, France, and colleagues conducted a phase 3 randomized trial involving patients with PPR. Participants were randomized to receive once-daily IVM 1 percent cream (478 participants) or twice-daily MTZ 0.75 percent cream (484 participants) for 16 weeks. Inflammatory lesion counts and Investigator's Global Assessment (IGA) were used to assess efficacy.
The researchers found that IVM 1 percent was significantly superior to MTZ 0.75 percent at week 16 in terms of reduction in inflammatory lesions from baseline (83.0 versus 73.7 percent; P < 0.001). This superiority was observed as early as week three. IVM 1 percent was also superior in terms of IGA results (subjects 'clear' or 'almost clear') (84.9 versus 75.4 percent; P < 0.001). Comparable adverse event incidence was seen between the groups; local tolerability was superior for IVM 1 percent. Global improvement was rated as 'excellent' or 'good' by more patients receiving IVM.
"In conclusion, while MTZ 0.75 percent cream has been the standard treatment for the papulopustular lesions of rosacea, its efficacy is now surpassed by that of IVM along with the advantage of once-daily dosing and high patient satisfaction," the authors write.
Two authors disclosed financial ties to Galderma R&D, which manufactures ivermectin and funded the study.
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(HealthDay)—For patients with papulopustular rosacea (PPR), once-daily ivermectin 1 percent cream (IVM 1 percent) is superior to twice-daily metronidazole (MTZ 0.75 percent) cream, according to a study published in the April issue of the British Journal of Dermatology.
Alain Taieb, M.D., Ph.D., from Hôpital Saint-André in Bordeaux, France, and colleagues conducted a phase 3 randomized trial involving patients with PPR. Participants were randomized to receive once-daily IVM 1 percent cream (478 participants) or twice-daily MTZ 0.75 percent cream (484 participants) for 16 weeks. Inflammatory lesion counts and Investigator's Global Assessment (IGA) were used to assess efficacy.
The researchers found that IVM 1 percent was significantly superior to MTZ 0.75 percent at week 16 in terms of reduction in inflammatory lesions from baseline (83.0 versus 73.7 percent; P < 0.001). This superiority was observed as early as week three. IVM 1 percent was also superior in terms of IGA results (subjects 'clear' or 'almost clear') (84.9 versus 75.4 percent; P < 0.001). Comparable adverse event incidence was seen between the groups; local tolerability was superior for IVM 1 percent. Global improvement was rated as 'excellent' or 'good' by more patients receiving IVM.
"In conclusion, while MTZ 0.75 percent cream has been the standard treatment for the papulopustular lesions of rosacea, its efficacy is now surpassed by that of IVM along with the advantage of once-daily dosing and high patient satisfaction," the authors write.
Two authors disclosed financial ties to Galderma R&D, which manufactures ivermectin and funded the study.
Explore further: Propranolol, doxycycline combo safe, effective in rosacea
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2015 HealthDay. All rights reserved.
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Propranolol, doxycycline combo safe, effective in rosacea
(HealthDay)—For patients with rosacea, combination treatment with propranolol and doxycycline is effective and safe, according to a study published in the January issue of the Journal of Dermatology.
AAD: Telangiectatic photoaging distinct from rosacea subtype
(HealthDay)—Telangiectatic photoaging (TP) is a distinct dermatological disorder from erythematotelangiectatic subtype of rosacea (ETR), according to a study published online March 23 in JAMA Dermatology. The re ...
First IVM babies born in United Kingdom
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Oral contraceptive equal to antibiotics for acne care
(HealthDay)—At six months, oral contraceptive pills (OCPs) are comparable to systemic antibiotics for acne management, according to a review published in the September issue of the Journal of the American Ac ...
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(HealthDay)—Opioid-induced constipation (OIC) is significant among noncancer pain patients, according to a study published online March 20 in Pain Medicine.
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