(HealthDay)—Pediatric discoid lupus erythematosus (DLE) carries a significant risk of progression to systemic lupus erythematosus (SLE), according to a review published in the April issue of the Journal of the American Academy of Dermatology.
Lisa M. Arkin, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues retrospectively reviewed 40 patients with DLE to assess the risk of progression.
The researchers found that 15 percent (six patients) of 40 patients presented with DLE as a manifestation of concurrent SLE. Nine of the remaining 34 patients (26 percent) eventually met SLE criteria, while 15 (44 percent) developed laboratory abnormalities without meeting SLE criteria. Skin-limited disease was only seen in 10 patients (29 percent). The greatest risk of progression to SLE was in the first year after DLE diagnosis, while the average age at progression was 11 years. The majority of patients (89 percent) with SLE met diagnostic criteria with mucocutaneous disease (discoid lesions, malar rash, oral and nasal ulcers, photosensitivity), positive antibodies, and/or cytopenia without developing end-organ damage.
"In pediatric patients, DLE carries a significant risk of progression to SLE but may predict a milder phenotype of systemic disease," the authors write.
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(HealthDay)—Pediatric discoid lupus erythematosus (DLE) carries a significant risk of progression to systemic lupus erythematosus (SLE), according to a review published in the April issue of the Journal of the American Academy of Dermatology.
Lisa M. Arkin, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues retrospectively reviewed 40 patients with DLE to assess the risk of progression.
The researchers found that 15 percent (six patients) of 40 patients presented with DLE as a manifestation of concurrent SLE. Nine of the remaining 34 patients (26 percent) eventually met SLE criteria, while 15 (44 percent) developed laboratory abnormalities without meeting SLE criteria. Skin-limited disease was only seen in 10 patients (29 percent). The greatest risk of progression to SLE was in the first year after DLE diagnosis, while the average age at progression was 11 years. The majority of patients (89 percent) with SLE met diagnostic criteria with mucocutaneous disease (discoid lesions, malar rash, oral and nasal ulcers, photosensitivity), positive antibodies, and/or cytopenia without developing end-organ damage.
"In pediatric patients, DLE carries a significant risk of progression to SLE but may predict a milder phenotype of systemic disease," the authors write.
Explore further: Uranium exposure tied to lupus
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2015 HealthDay. All rights reserved.
Medical Xpress on facebook
Related Stories
Predictors of organ damage identified in patients with SLE
(HealthDay)—Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus (SLE), according ...
Identifying targets of autoantibodies
Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems. The host factors that are targeted by autoantibodies produced by SLE patients ...
Lupus ups risk of spontaneous subarachnoid hemorrhage
(HealthDay)—Patients with systemic lupus erythematosus (SLE) have an increased risk of spontaneous subarachnoid hemorrhage (SAH) and increased mortality after SAH, according to a study published in the ...
Uranium exposure tied to lupus
(HealthDay)—High uranium exposure is associated with systemic lupus erythematosus (SLE), according to a study published online Aug. 7 in Arthritis & Rheumatology.
Canadian pediatric lupus severity varies with ethnicity
(HealthDay)—While Canadian children with systemic lupus erythematosus (SLE) differ in disease characteristics and severity by ethnicity, treatment, disease activity, and irreversible organ damage are similar ...
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Botulinum toxin-A beneficial in painful diabetic neuropathy
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Adam C. Levine, M.D., an emergency medicine physician at Rhode Island Hospital and The Miriam Hospital who treated Ebola-infected patients in Liberia last year, used his field experience to create a tool ...
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Bone loss may be a sign of poor heart health in patients on dialysis, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). Monitoring bone loss in dialysis pati ...
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