Women with early-stage breast cancer in one breast are increasingly opting to undergo a more aggressive operation to remove both breasts called contralateral prophylactic mastectomy (CPM). Rates of double mastectomies have more than doubled over the last decade for women with early-stage cancer, but for women with cancer in one breast, having the healthy breast removed may not provide a survival benefit, according to new research findings presented today at the 2013 Clinical Congress of the American College of Surgeons.
According to the American Cancer Society, more than 232,000 women are diagnosed with breast cancer in the U.S. every year,* making breast cancer the second most common type of cancer in women, after skin cancer. Many women who face this diagnosis worry about cancer recurring in the healthy breast and therefore choose to have both breasts removed, even though the risk of developing cancer in the other breast is very low. Women at high risk include those with a family history of breast or ovarian cancer and women who test positive for the BRCA1 and BRCA2 gene mutations.
Importantly, until now no study has looked at the decision-making processes that lead women to choose CPM. "There have been several studies in the last couple of years indicating that there may be a survival benefit for selected patients by having their healthy breast removed," said study coauthor Todd M. Tuttle, MD, FACS, chief of surgical oncology, University of Minnesota, Minneapolis. "This research will provide physicians and patients with accurate and easily understood information about whether removal of the healthy breast will impact their survival at all."
To better understand the effect of CPM on life expectancy, the researchers conducted an analytic modeling study among women without a BRCA gene mutation. Within this group, the researchers compared women who underwent CPM with women who did have early-stage breast cancer in one breast and no prophylactic operation to remove the second breast.
The study authors primarily analyzed data from the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) and the Surveillance, Epidemiology, and End Results (SEER) program to determine the risk of developing contralateral breast cancer (CBC), dying from CBC, dying from primary breast cancer, and the reduction in CBC due to CPM. The two databases include information on the treatment and survival of early breast cancer and include more than 100,000 women who have participated in randomized trials over the last 30 years across the United States.
For the study, the researchers estimated the life expectancy gain of CPM among sub-groups of women newly diagnosed with cancer in one breast by age 40 to 60 years, estrogen receptor status as positive or negative, and stage of cancer I or II. They found that the maxi- mum life expectancy gain for women who underwent CPM was six months for all scenarios including age, estrogen receptor status, and cancer stage groups.
Because many women are driven by their fears of contracting a second cancer in their healthy breast, they choose a double mastectomy, the more aggressive treatment. This procedure is a bigger operation associated with a longer recovery period and potentially more complications. Thus, experts are concerned that some patients are being overtreated with a prophylactic procedure.
"I think this decision model study will provide women who are considering these extensive operations with more accurate information about whether or not CPM is going to improve their survival," Dr. Tuttle said. With this analytic modeling tool, women and physicians can make more informed and better decisions when choosing between different treatments. These results can help educate women that a contralateral mastectomy will not improve their survival rate if they don't have hereditary breast cancer, he explained.
"This information may ultimately help them answer an important question: 'If I have that opposite breast removed, is that procedure really going to improve the likelihood that I will be alive 10 to 20 years from now?'"
Explore further: Young breast cancer patients often overestimate benefit of having healthy breast removed
More information: *American Cancer Society, www.cancer.org/cancer/breastcancer/overviewguide/breast-cancer-overview-key-statistics. Accessed August 28, 2013.
Medical Xpress on facebook
Related Stories
Young breast cancer patients often overestimate benefit of having healthy breast removed
Sep 16, 2013
Young women with breast cancer often overestimate the odds that cancer will occur in their other, healthy breast, and decide to have the healthy breast surgically removed, a survey conducted by Dana-Farber Cancer Institute ...
Growing use of MRIs leading to more invasive breast cancer surgery
Aug 14, 2013
Heavy use of magnetic resonance imaging (MRI) may be leading to unnecessary breast removal in older women with breast cancer, according to a study by Yale School of Medicine researchers in the current issue of Breast Cancer Re ...
Most women who have double mastectomy don't need it, study finds
Nov 27, 2012
About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, new research from the University of Michigan Comprehensive ...
Report: Breast cancer incidence rates converging among white and African-American women
Oct 01, 2013
Breast cancer incidence rates increased slightly among African American women from 2006 to 2010, bringing those rates closer to the historically higher rates among white women, according to a new analysis by American Cancer ...
Contralateral prophylactic mastectomy offers limited gains for breast cancer patients
Dec 08, 2011
Contralateral prophylactic mastectomy (CPM), a procedure that removes the unaffected breast in patients with cancer in one breast, provides only a modest increase in life expectancy, according to a new study by researchers ...
Recommended for you
Use of post-operative blood clot rate as measure of hospital quality may be flawed
4 hours ago
A new study published by JAMA questions using the rate of postoperative blood clots as a hospital quality measure. The study is being released early online to coincide with the American College of Surgeons 2013 Annual Clinic ...
High-dose rhBMP linked to increased incidence of cancer
Oct 04, 2013
(HealthDay)—Patients receiving high-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) as part of spine surgery have an increased risk of cancer and may be at risk for major complications, according ...
VTE occurs in 13 percent of head, neck cancer surgery cases
Oct 04, 2013
(HealthDay)—Venous thromboembolism (VTE) rates in a prospective cohort of head and neck cancer surgical patients are higher than previously reported in retrospective studies, according to research published ...
Ethics of the commercialization of plastic surgery considered
Oct 04, 2013
(HealthDay)—Despite the increasing commercialization of plastic surgery, surgeons have a responsibility to provide individualized treatment to each patient, according to a study published in the September ...
Johns Hopkins experts devise a way to cut radiation exposure in children needing repeat brain scans
Oct 03, 2013
A team of pediatric neurosurgeons and neuroradiologists at the Johns Hopkins Children's Center has developed a way to minimize dangerous radiation exposure in children with a condition that requires repeat CT scans of the ...
Massachusetts health law cut race gap for certain surgeries: study
Oct 02, 2013
(HealthDay)—Blacks and Hispanics in Massachusetts became more likely to have minimally invasive laparoscopic surgery on their appendix and gallbladder after the state's 2006 health care reforms expanded ...
User comments
© Medical Xpress 2011-2013, Phys.org network
Women with early-stage breast cancer in one breast are increasingly opting to undergo a more aggressive operation to remove both breasts called contralateral prophylactic mastectomy (CPM). Rates of double mastectomies have more than doubled over the last decade for women with early-stage cancer, but for women with cancer in one breast, having the healthy breast removed may not provide a survival benefit, according to new research findings presented today at the 2013 Clinical Congress of the American College of Surgeons.
According to the American Cancer Society, more than 232,000 women are diagnosed with breast cancer in the U.S. every year,* making breast cancer the second most common type of cancer in women, after skin cancer. Many women who face this diagnosis worry about cancer recurring in the healthy breast and therefore choose to have both breasts removed, even though the risk of developing cancer in the other breast is very low. Women at high risk include those with a family history of breast or ovarian cancer and women who test positive for the BRCA1 and BRCA2 gene mutations.
Importantly, until now no study has looked at the decision-making processes that lead women to choose CPM. "There have been several studies in the last couple of years indicating that there may be a survival benefit for selected patients by having their healthy breast removed," said study coauthor Todd M. Tuttle, MD, FACS, chief of surgical oncology, University of Minnesota, Minneapolis. "This research will provide physicians and patients with accurate and easily understood information about whether removal of the healthy breast will impact their survival at all."
To better understand the effect of CPM on life expectancy, the researchers conducted an analytic modeling study among women without a BRCA gene mutation. Within this group, the researchers compared women who underwent CPM with women who did have early-stage breast cancer in one breast and no prophylactic operation to remove the second breast.
The study authors primarily analyzed data from the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) and the Surveillance, Epidemiology, and End Results (SEER) program to determine the risk of developing contralateral breast cancer (CBC), dying from CBC, dying from primary breast cancer, and the reduction in CBC due to CPM. The two databases include information on the treatment and survival of early breast cancer and include more than 100,000 women who have participated in randomized trials over the last 30 years across the United States.
For the study, the researchers estimated the life expectancy gain of CPM among sub-groups of women newly diagnosed with cancer in one breast by age 40 to 60 years, estrogen receptor status as positive or negative, and stage of cancer I or II. They found that the maxi- mum life expectancy gain for women who underwent CPM was six months for all scenarios including age, estrogen receptor status, and cancer stage groups.
Because many women are driven by their fears of contracting a second cancer in their healthy breast, they choose a double mastectomy, the more aggressive treatment. This procedure is a bigger operation associated with a longer recovery period and potentially more complications. Thus, experts are concerned that some patients are being overtreated with a prophylactic procedure.
"I think this decision model study will provide women who are considering these extensive operations with more accurate information about whether or not CPM is going to improve their survival," Dr. Tuttle said. With this analytic modeling tool, women and physicians can make more informed and better decisions when choosing between different treatments. These results can help educate women that a contralateral mastectomy will not improve their survival rate if they don't have hereditary breast cancer, he explained.
"This information may ultimately help them answer an important question: 'If I have that opposite breast removed, is that procedure really going to improve the likelihood that I will be alive 10 to 20 years from now?'"
Explore further: Young breast cancer patients often overestimate benefit of having healthy breast removed
More information: *American Cancer Society, www.cancer.org/cancer/breastcancer/overviewguide/breast-cancer-overview-key-statistics. Accessed August 28, 2013.
Medical Xpress on facebook
Related Stories
Young breast cancer patients often overestimate benefit of having healthy breast removed
Sep 16, 2013
Young women with breast cancer often overestimate the odds that cancer will occur in their other, healthy breast, and decide to have the healthy breast surgically removed, a survey conducted by Dana-Farber Cancer Institute ...
Growing use of MRIs leading to more invasive breast cancer surgery
Aug 14, 2013
Heavy use of magnetic resonance imaging (MRI) may be leading to unnecessary breast removal in older women with breast cancer, according to a study by Yale School of Medicine researchers in the current issue of Breast Cancer Re ...
Most women who have double mastectomy don't need it, study finds
Nov 27, 2012
About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, new research from the University of Michigan Comprehensive ...
Report: Breast cancer incidence rates converging among white and African-American women
Oct 01, 2013
Breast cancer incidence rates increased slightly among African American women from 2006 to 2010, bringing those rates closer to the historically higher rates among white women, according to a new analysis by American Cancer ...
Contralateral prophylactic mastectomy offers limited gains for breast cancer patients
Dec 08, 2011
Contralateral prophylactic mastectomy (CPM), a procedure that removes the unaffected breast in patients with cancer in one breast, provides only a modest increase in life expectancy, according to a new study by researchers ...
Recommended for you
Use of post-operative blood clot rate as measure of hospital quality may be flawed
4 hours ago
A new study published by JAMA questions using the rate of postoperative blood clots as a hospital quality measure. The study is being released early online to coincide with the American College of Surgeons 2013 Annual Clinic ...
High-dose rhBMP linked to increased incidence of cancer
Oct 04, 2013
(HealthDay)—Patients receiving high-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) as part of spine surgery have an increased risk of cancer and may be at risk for major complications, according ...
VTE occurs in 13 percent of head, neck cancer surgery cases
Oct 04, 2013
(HealthDay)—Venous thromboembolism (VTE) rates in a prospective cohort of head and neck cancer surgical patients are higher than previously reported in retrospective studies, according to research published ...
Ethics of the commercialization of plastic surgery considered
Oct 04, 2013
(HealthDay)—Despite the increasing commercialization of plastic surgery, surgeons have a responsibility to provide individualized treatment to each patient, according to a study published in the September ...
Johns Hopkins experts devise a way to cut radiation exposure in children needing repeat brain scans
Oct 03, 2013
A team of pediatric neurosurgeons and neuroradiologists at the Johns Hopkins Children's Center has developed a way to minimize dangerous radiation exposure in children with a condition that requires repeat CT scans of the ...
Massachusetts health law cut race gap for certain surgeries: study
Oct 02, 2013
(HealthDay)—Blacks and Hispanics in Massachusetts became more likely to have minimally invasive laparoscopic surgery on their appendix and gallbladder after the state's 2006 health care reforms expanded ...
User comments
© Medical Xpress 2011-2013, Phys.org network
0 comments:
Post a Comment