A study of patients in the United Kingdom suggests widespread prescribing of the medication levothyroxine sodium to boost thyroid function among patients with borderline high levels of the thyroid-stimulating hormone thyrotropin (a sign of low thyroid function), raising the possibility of overtreatment, according to a study published by JAMA Internal Medicine.
Hypothyroidism (low thyroid function) is one of the most common chronic conditions in Western populations, with levothyroxine prescriptions having increased in the United States, England and Wales, according to the study background.
Researchers note that while thyroid function testing has increased, likely resulting in detection of more cases, an additional factor contributing to more prescriptions of thyroid medication may be the lowering of the thyrotropin threshold at which levothyroxine treatment is started in patients. If the increase in prescriptions is due to a lower threshold for treatment, then treatment may result in less benefit and more harm. Overtreatment is associated with an increased risk of fractures and atrial fibrillation (abnormal heart beat), according to researchers.
Peter N. Taylor, M.Sc., M.R.C.P., of the Cardiff University School of Medicine, United Kingdom, and colleagues examined trends in thyrotropin levels before and after levothyroxine therapy.
Researchers used data from the United Kingdom Clinical Practice Research Datalink and identified 52,298 patients who received a levothyroxine prescription between 2001 and 2009.
American Thyroid Association guidelines recommend considering levothyroxine therapy at thyrotropin levels of 10 mIU/L or less when there are clear symptoms of hypothyroidism, positive thyroid autoantibodies or evidence of atherosclerotic cardiovascular disease (hardening of the arteries) or heart failure. Treatment of patients with thyrotropin levels at or below 10 mIU/L without symptoms may cause more harm than good and may represent overtreatment.
The study findings indicate that between 2001 and 2009, the median (midpoint) thyrotropin level at the start of levothyroxine treatment declined from 8.7 to 7.9 mIU/L, with an increase in the odds of having levothyroxine therapy start at a thyrotropin level of 10 mIU/L or less.
"In the United Kingdom, 1.6 million individuals are on long-term levothyroxine regimens, most of whom have been prescribed it for primary hypothyroidism. If current practice continues, up to 30 percent of persons receiving levothyroxine therapy may have been prescribed it without an accepted indication and with the potential for net harm if they develop even a low thyrotropin level," the study concludes.
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More information: JAMA Intern Med. Published online October 7, 2013. DOI: 10.1001/jamainternmed.2013.11312
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A study of patients in the United Kingdom suggests widespread prescribing of the medication levothyroxine sodium to boost thyroid function among patients with borderline high levels of the thyroid-stimulating hormone thyrotropin (a sign of low thyroid function), raising the possibility of overtreatment, according to a study published by JAMA Internal Medicine.
Hypothyroidism (low thyroid function) is one of the most common chronic conditions in Western populations, with levothyroxine prescriptions having increased in the United States, England and Wales, according to the study background.
Researchers note that while thyroid function testing has increased, likely resulting in detection of more cases, an additional factor contributing to more prescriptions of thyroid medication may be the lowering of the thyrotropin threshold at which levothyroxine treatment is started in patients. If the increase in prescriptions is due to a lower threshold for treatment, then treatment may result in less benefit and more harm. Overtreatment is associated with an increased risk of fractures and atrial fibrillation (abnormal heart beat), according to researchers.
Peter N. Taylor, M.Sc., M.R.C.P., of the Cardiff University School of Medicine, United Kingdom, and colleagues examined trends in thyrotropin levels before and after levothyroxine therapy.
Researchers used data from the United Kingdom Clinical Practice Research Datalink and identified 52,298 patients who received a levothyroxine prescription between 2001 and 2009.
American Thyroid Association guidelines recommend considering levothyroxine therapy at thyrotropin levels of 10 mIU/L or less when there are clear symptoms of hypothyroidism, positive thyroid autoantibodies or evidence of atherosclerotic cardiovascular disease (hardening of the arteries) or heart failure. Treatment of patients with thyrotropin levels at or below 10 mIU/L without symptoms may cause more harm than good and may represent overtreatment.
The study findings indicate that between 2001 and 2009, the median (midpoint) thyrotropin level at the start of levothyroxine treatment declined from 8.7 to 7.9 mIU/L, with an increase in the odds of having levothyroxine therapy start at a thyrotropin level of 10 mIU/L or less.
"In the United Kingdom, 1.6 million individuals are on long-term levothyroxine regimens, most of whom have been prescribed it for primary hypothyroidism. If current practice continues, up to 30 percent of persons receiving levothyroxine therapy may have been prescribed it without an accepted indication and with the potential for net harm if they develop even a low thyrotropin level," the study concludes.
Explore further: Animal thyroid extract as effective as T4 in treating hypothyroidism
More information: JAMA Intern Med. Published online October 7, 2013. DOI: 10.1001/jamainternmed.2013.11312
Medical Xpress on facebook
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Animal thyroid extract as effective as T4 in treating hypothyroidism
Jun 17, 2013
Desiccated thyroid extract (DTE), derived from crushed preparations of animal thyroid glands, is a safe and effective alternative to standard T4 therapy in hypothyroid patients, a new study finds. The results will be presented ...
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Apr 23, 2012
Treatment of subclinical hypothyroidism with the medication levothyroxine appears to be related to fewer ischemic heart disease events in younger patients but this finding was not evident in older patients, according to a ...
Soy linked to exacerbated congenital hypothyroidism
Aug 20, 2012
(HealthDay) -- Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 ...
Concern over 'excessive' doses of thyroid drugs for older patients
Apr 29, 2011
Many older adults may be taking "excessive" doses of drugs for thyroid problems which can lead to an increased risk of fractures, finds a study published in the British Medical Journal today.
Antenatal thyroid screening fails to improve IQ in 3-year-olds
Feb 08, 2012
Children of mothers screened and treated for reduced thyroid function during pregnancy show no signs of improved IQ compared to women who receive no treatment, new research has uncovered.
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