Applying ice to a muscle after injury is a commonly prescribed therapy for treating muscle bruises. But does it really speed recovery time and help the muscle to heal?
Researchers from the Institute of Health and Biomedical Innovation at Queensland University of Technology in Australia investigated whether icing after a muscle impact injury contributed to new blood vessel formation (angiogenesis) and muscle regeneration.
The research team looked at two groups of rats with thigh contusions. One group received ice within five minutes of injury for 20 minutes. The second group received no ice. During the acute phase three days after injury, infiltration of inflammatory cells and the markers of angiogenesis—vascular endothelial growth factor (VEGF) and von Willebrand factor (vWF)—were lower in the icing group compared with the non-icing group. During the early repair phase (seven days), inflammatory cell numbers were higher, while VEGF and vWF expression remained lower, in the icing group compared with the non-icing group. In the late repair phase (28 days), inflammatory cell numbers, VEGF expression and the number of regenerating muscle fibers were all greater in the icing group (causing less inflammation and swelling) compared with the non-icing group. Muscle fiber cross-sectional area was similar between the groups at seven and 28 days after injury.
Despite popular belief, inflammation can be an important process in tissue regeneration. The results suggest that ice may delay inflammation, angiogenesis and the formation of new muscle fibers during recovery from severe muscle injury. "These findings challenge the practice of using ice to treat muscle injuries," the research team wrote. Practitioners should therefore reconsider how they use treatments such as icing and non-steroidal anti-inflammatory drugs to manage acute soft tissue injuries.
Jonathan Peake will present "The Effects of Topical Icing after Contusion Injury on Angiogenesis in Regenerating Skeletal Muscle" in a poster session on Monday, March 30, at the Experimental Biology Meeting (Boston Convention and Exhibition Center.
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Applying ice to a muscle after injury is a commonly prescribed therapy for treating muscle bruises. But does it really speed recovery time and help the muscle to heal?
Researchers from the Institute of Health and Biomedical Innovation at Queensland University of Technology in Australia investigated whether icing after a muscle impact injury contributed to new blood vessel formation (angiogenesis) and muscle regeneration.
The research team looked at two groups of rats with thigh contusions. One group received ice within five minutes of injury for 20 minutes. The second group received no ice. During the acute phase three days after injury, infiltration of inflammatory cells and the markers of angiogenesis—vascular endothelial growth factor (VEGF) and von Willebrand factor (vWF)—were lower in the icing group compared with the non-icing group. During the early repair phase (seven days), inflammatory cell numbers were higher, while VEGF and vWF expression remained lower, in the icing group compared with the non-icing group. In the late repair phase (28 days), inflammatory cell numbers, VEGF expression and the number of regenerating muscle fibers were all greater in the icing group (causing less inflammation and swelling) compared with the non-icing group. Muscle fiber cross-sectional area was similar between the groups at seven and 28 days after injury.
Despite popular belief, inflammation can be an important process in tissue regeneration. The results suggest that ice may delay inflammation, angiogenesis and the formation of new muscle fibers during recovery from severe muscle injury. "These findings challenge the practice of using ice to treat muscle injuries," the research team wrote. Practitioners should therefore reconsider how they use treatments such as icing and non-steroidal anti-inflammatory drugs to manage acute soft tissue injuries.
Jonathan Peake will present "The Effects of Topical Icing after Contusion Injury on Angiogenesis in Regenerating Skeletal Muscle" in a poster session on Monday, March 30, at the Experimental Biology Meeting (Boston Convention and Exhibition Center.
Explore further: Poison dart frog inspires new way to de-ice planes
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Curiosity about the way a particular tropical frog releases a toxic substance through its skin to protect itself led Arizona State University engineer Konrad Rykaczewski to an idea for a new anti-icing technique ...
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A new research study published in The FASEB Journal may change how sports injuries involving muscle tissue are treated, as well as how much patient monitoring is necessary when potent anti-inflammatory drugs are prescribed for a ...
Out-of-step cells spur muscle fibrosis in Duchenne muscular dystrophy patients
Like a marching band falling out of step, muscle cells fail to perform in unison in patients with Duchenne muscular dystrophy. A new study in The Journal of Cell Biology reveals how this breakdown leads ...
Putting a 'HEX' on muscle regeneration
A complex genetic regulatory network mediates the regeneration of adult skeletal muscles. In this issue of the Journal of Clinical Investigation, researchers at the State University of New York Downstate Medical Center in Bro ...
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After an incomplete spinal cord injury, the body can partially recover basic motor function. So-called muscle spindles and associated sensory circuits back to the spinal cord promote the establishment of ...
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